Learning and memory as a function of age in Down syndrome: a study using animal-based tasks.

Individuals with Down syndrome (DS) are at a high risk for developing Alzheimer disease (AD) after the age 40; however, low levels of intellectual functioning, coupled with impaired language ability, confound the detection of AD. Comparative neuropsychological tests developed in animal models of aging and cognition do not require intact language function and can be useful for detecting changes in cognition. Experimental paradigms used to detect age-dependent cognitive deficits in animal models were applied in the present study to measure cognitive function in a group of 20 adults with DS ranging in age from 22 to 58 years.

Personality testing and epilepsy: comparison of two MMPI-2 correction procedures.

The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) is widely used for assessing psychopathology. However, its reliability in people with neurologic disease has been questioned. This concern is especially true for epilepsy, a disease with symptoms, i.

Measuring personality and emotional functioning in multiple sclerosis: a cautionary note.

Changes in personality and emotional status are common in individuals with multiple sclerosis (MS). The purpose of this study was to examine results based on the MMPI-2 before and following application of a statistical correction procedure (Gass, 1992). This was done to help determine changes in scale score elevations when items containing actual physical symptoms are identified and statistically removed.