Optimization of Electrospun Bilayer Vascular Grafts through Assessment of the Mechanical Properties of Monolayers.

Small-diameter vascular grafts must be obtained with the most appropriate materials and design selection to harmoniously display a variety of features, including adequate tensile strength, compliance, burst strength, biocompatibility, and biodegradability against challenging physiological and hemodynamic conditions. In this study, monolayer vascular grafts with randomly distributed or radially oriented fibers are produced using neat, blended, and copolymer forms of polycaprolactone (PCL) and poly(lactic acid) (PLA) via the electrospinning technique. The blending ratio is varied by increasing 10 in the range of 50-100%.

Investigation of biodegradability and cellular activity of PCL/PLA and PCL/PLLA electrospun webs for tissue engineering applications.

Biodegradability and cellular activity are key performance indicators that should be prioritized for tissue engineering applications. Biopolymer selection, determination of necessary structural properties, and their synergistic interactions play an active role in obtaining the expected biodegradability and biological activity from scaffolds. In this study, it is aimed to produce electrospun webs with improved biocompatibility by blending polycaprolactone (PCL) with polylactic acid (PLA) and poly-l-lactide (PLLA), and examine the effect of biopolymer selection and blend ratio on the biodegradability and cellular activity of surfaces.

Development of biodegradable webs of PLA/PCL blends prepared via electrospinning: Morphological, chemical, and thermal characterization.

Biodegradable polymers have a mean role to mimic native tissues and allow cells to penetrate, grow, and proliferate with their advanced features in tissue engineering applications. The physiological, chemical, mechanical, and biological qualities of the surfaces, which are presented from biodegradable polymers, affect the final properties of the scaffolds. In this study, it is aimed to produce fibrous webs by electrospinning method for tissue engineering applications using two different biopolymers, polylactic acid (PLA) and polycaprolactone (PCL).