Publications by authors named "Jansen W"

Integration of child mental health services in general practice may improve early detection and treatment and reduce strain on specialized services. In this study we investigated whether outpatient mental health care utilization and associated costs in children and adolescents were affected by the introduction of youth mental health practice nurses (YMHPNs) in general practice. We linked healthcare data of the Rijnmond Primary Care Database to municipal registry data on child outpatient mental health care expenditures between 2019 and 2022.

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  • Inappropriate therapy (IAT) is a significant issue associated with implantable cardiac defibrillator (ICD) therapy, particularly highlighted in early subcutaneous ICD (S-ICD) studies which showed high rates of inappropriate shocks (IAS).
  • The PRAETORIAN trial, an international study with 849 patients, found no major differences in IAT and IAS rates between S-ICD and transvenous ICD (TV-ICD) groups, as both groups had similar cumulative incidences.
  • Key predictors for IAT varied between the two groups, with TV-ICD patients experiencing IAT mainly from supraventricular tachycardias, while S-ICD patients faced issues from cardiac oversensing
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In recent years, integrated veterinary herd health management (VHHM), improving animal health, welfare, food safety, public health, farm management, and economics, has become ever-more important in the European Union due to structural and regulatory advancements. A mixed-methods study analyzed the current state and gaps in VHHM education and training across Europe. Data from 41 European veterinary institutions showed that 83% ( = 34/41) offered VHHM education, either as standalone courses and/or integrated into other subjects.

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The predictive brain hypothesis suggests that perception can be interpreted as the process of minimizing the error between predicted perception tokens generated via an internal world model and actual sensory input tokens. When implementing working examples of this hypothesis in the context of in-air sonar, significant difficulties arise due to the sparse nature of the reflection model that governs ultrasonic sensing. Despite these challenges, creating consistent world models using sonar data is crucial for implementing predictive processing of ultrasound data in robotics.

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  • The S-ICD was created to eliminate lead-related issues found in the TV-ICD, as it is an external device that sits under the skin rather than using leads inside the body.
  • This analysis comes from the PRAETORIAN trial, where patients were randomly assigned to either S-ICD or TV-ICD and assessed for quality of life through various questionnaires at different stages.
  • Results showed no significant differences in physical and mental well-being between the groups, but patients who experienced a shock recently reported lower social functioning and emotional health compared to those who did not.
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A commonly applied analgesic therapy for patients with severe abdominal pain due to cancer-related pain in the upper abdomen, is coeliac plexus neurolysis (CPN). Herein, a combination product of phenol and an iodine contrast agent are injected simultaneously. The chemical stability of such a combination product is unknown, and no chromatographic method is yet available that describes the simultaneous quantification of phenol and iomeprol.

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Alzheimer's disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its etiology. Previous evidence has implicated disturbed insulin signaling as a key mechanism that plays a role in both neurodegenerative diseases such as AD and comorbid somatic diseases such as diabetes mellitus type 2 (DM2). In this study, we analysed available genome-wide association studies (GWASs) of AD and somatic insulin-related diseases and conditions (SID), i.

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Major efforts have been made to reduce the use of colistin in livestock since the discovery of the plasmid-borne mobile colistin resistance () gene in a decade ago, to curb the burden of its potential transmission to other bacterial species, spread between animals, humans and the environment. This study explored the longitudinal prevalence and characteristics of colistin-resistant and extended-spectrum beta-lactamase-producing (ESBL) via in vivo fecal and ex vivo carcass swabs from two batches of conventional indoor and organic outdoor Wallon meat sheep from birth to slaughter in 2020 and 2021. Antimicrobial susceptibility testing via broth microdilution revealed that n = 16/109 (15%) isolates from conventional meat lamb fecal samples had a reduced colistin sensitivity (MIC = 0.

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Background: General practitioners (GPs) could play an important role in the management of overweight and obesity in children. However, GPs experience different barriers and are in need of supportive tools. In order to support GPs to identify, address and refer these children, new tools should be developed.

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  • This study examined the link between plasma biomarkers indicating endothelial dysfunction and cognitive performance in a sample of 9,414 older adults from the Netherlands, aged 57 to 93 years.
  • Researchers created a composite score from three specific biomarkers and assessed various cognitive functions like executive function and memory.
  • Results indicated a small, consistent association between higher endothelial dysfunction scores and poorer cognitive performance, but no evidence suggested that these markers influenced cognitive decline over time.
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Introduction: The majority of children fails to have a healthy diet. Providing a healthy lunch at school is a way to target all children, regardless of ethnic and socioeconomic background. This study aims to investigate the effectivity and feasibility of a co-created healthy school lunch in disadvantaged neighbourhoods of the city of Rotterdam, the Netherlands.

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Background: Overweight and obesity in children is a major health problem. General practice might be a promising setting for identifying and for the first steps in the management of overweight and obesity in children.

Objective: To explore opinions, needs and preferences about the role of general practice in the management of overweight and obesity in children from the perspectives of Dutch general practitioners (GPs), practice nurses (PNs) and parents of children with and without overweight.

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  • The study investigated the relationship between glucose metabolism and the development of tau pathology, a hallmark of Alzheimer's disease, in middle-aged adults without dementia.
  • Researchers analyzed data from 288 participants, examining their fasting plasma glucose and insulin levels and later PET scans for amyloid-β and tau loads.
  • Results showed that elevated plasma glucose correlated with increased tau load after 14 years, particularly in individuals who were not carriers of the APOE ε4 allele, while insulin levels and HOMA-IR did not show significant associations with either amyloid-β or tau.
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Background: The Exceptional Medical Expenses Act (EMEA) guaranteed public financing for the costs of end-of-life care in The Netherlands until 2015. A life expectancy shorter than three months was a prerequisite for a patient to qualify.

Objective: To estimate survival and its potential predictors using the start date of EMEA funded end-of-life care as time origin, and to calculate the ensuing costs.

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Background: Obesity in adolescence has increased in the last decades. Adolescents fail to meet the recommended guidelines for physical activity (PA) and healthy diet. Adolescents with a low socioeconomic status (SES) particularly seem to have fewer healthy lifestyle behaviours.

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Context: Adolescence is an optimal period to promote healthy lifestyles because behavior patterns are established in this stage. It has been suggested that engaging youth increases the effectiveness of interventions, but an overview is lacking.

Objective: This study aims to evaluate the effectiveness of participatory research (PR) interventions, where adolescents (11-18 years old) from high-income countries had a significant role in the intervention development and/or delivery, compared with no (PR) intervention control groups on obesity-related outcomes and healthy lifestyle behaviors (HLBs).

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In this paper, we introduce SonoNERFs, a novel approach that adapts Neural Radiance Fields (NeRFs) to model and understand the echolocation process in bats, focusing on the challenges posed by acoustic data interpretation without phase information. Leveraging insights from the field of optical NeRFs, our model, termed SonoNERF, represents the acoustic environment through Neural Reflectivity Fields. This model allows us to reconstruct three-dimensional scenes from echolocation data, obtained by simulating how bats perceive their surroundings through sound.

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Background: Establishing collaborations between cohort studies has been fundamental for progress in health research. However, such collaborations are hampered by heterogeneous data representations across cohorts and legal constraints to data sharing. The first arises from a lack of consensus in standards of data collection and representation across cohort studies and is usually tackled by applying data harmonization processes.

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Background: European adolescents do not eat enough fruits and vegetables and have a high sweets consumption. This study aims to analyse the changes in time of dietary behaviours related to sociodemographic characteristics, among European adolescents.

Methods: Health Behaviour in School Age Children data (2013/14 to 2017/18), of European adolescents, aged 11- to15-year-old, were used.

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  • The study investigates the relationship between insulin resistance (IR)-related conditions, like type 2 diabetes and obesity, and neuropsychiatric disorders, highlighting the complexity of their co-occurrence as a public health issue.
  • Researchers used genome-wide association studies (GWASs) with a large sample size to analyze genetic correlations between these conditions, identifying various genomic regions with significant local correlations.
  • The findings suggest that these correlated regions are linked to important biological pathways, indicating potential targets for treatments and a need for an integrated approach to understanding and managing these interconnected health problems.
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  • * Results showed that impaired glucose metabolism and DM status correlated with higher tau biomarkers, but not with amyloid-β, suggesting a specific association with tau in certain population settings.
  • * These findings highlight the importance of understanding the relationship between DM and AD biomarkers, which could improve diagnostics and treatment for both conditions.
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Background: Child mental health services are under major pressure worldwide. In the Netherlands, Youth Mental Health Practice Nurses (YMHPNs) have been introduced in general practice to improve access to care. In this study, we evaluated care delivered by YMHPNs.

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  • - A study of veterinarians in Europe revealed ongoing mental wellbeing issues, influenced by socio-economic and cultural factors, despite the profession's positive aspects.
  • - Surveys conducted in 2018/2019 and 2022/2023 assessed stress, medical leave needs, and mental wellbeing, highlighting that early-career and female veterinarians faced greater challenges.
  • - Results showed consistently high stress levels and low mental wellbeing scores, indicating an urgent need for improvements in workplace support, work/life balance, and job satisfaction in the veterinary field.
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  • Alzheimer's disease and vascular issues commonly affect the elderly, but how they impact cognitive decline is still unclear.
  • The study examined 227 patients from memory clinics for the combined effect of amyloid abnormalities and vascular burdens on cognitive decline, using various cognitive assessments and MRI data.
  • Results indicated that those with both amyloid abnormalities and vascular issues showed greater cognitive decline, but amyloid abnormalities were the main predictor of decline, suggesting vascular burden has a lesser role.
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Strengthening social support has been recognized as a potentially effective strategy to enhance parenting self-efficacy, but empirical evidence is limited. This study examined the association between perceived social support and parenting self-efficacy.Data of 647 parents of children aged 0-8 years, gathered in the CIKEO cohort study in the Netherlands, were analysed.

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