Is the small size of a breast cancer tumor the crucial point for successful medical treatment?

The presented case displays a clinical study of a cancer phenotype with a poor clinical outcome. Prediction of cancer development and effects of treatment at the beginning of the clinical stage is difficult as the knowledge of cancer process and all necessary parameters of the host body are limited. Cancer is mainly studied on the basis of biochemical-genetic processes and their morphological manifestation.

[Occupational tuberculosis in Slovakia and in the Czech Republic].

Study Objective: To conduct a retrospective 15-year study to monitor trends in the number of employees at risk for occupational tuberculosis (TB) (levels III and IV) in the Slovak Republic, and in particular in the sector of economic activities Q (health care and social assistance). Furthermore, to analyze reported cases of occupational TB and to compare the incidence and sex-specific and age-specific prevalence with the data reported in the Czech Republic.

Material And Methods: Data on the number of employees at risk of exposure to occupational TB were derived from the Automated Risk Classification System of the Slovak Republic.

Pregnancy-associated osteoporosis with eight fractures in the vertebral column treated with kyphoplasty and bracing: a case report.

Pregnancy-associated osteoporosis is a rare condition, which imposes multiple symptoms in the musculoskeletal system. Common complaints announced by patients are severe pain in the lower back, hips and the joints of the lower extremities with a reduced and less mobility status in general. Most of the patients' problems occur in the last trimester of pregnancy or postpartum and are often not diagnosed as side effects of osteoporosis but as problems associated with pregnancy.

Unusual clinical tumor development in axilla.

This work describes clinical development of a sarcoma in the left axilla of a 36-year-old woman. The macroscopic picture changed from the initial inflammatory reddening to globular resistance of 2.5 cm, suggestive of an enlarged lymph node.

[Validity of the oncological cytodiagnostics and colposcopy examination versus biopsy in cervical carcinoma prevention].

The Aim Of The Study: The basic praebioptic methods detecting the precancerous lesions of the uterine cervix are oncologic cytology (PAP smears) and colposcopy. However in the Czech Republic the incidence of the invasive carcinomas during the last 10 years did not considerably decrease. Therefore the goal of our study is to estimate the validity of the prebioptic methods and compare the results of praebioptic methods (procedures) versus biopsy.

[Optimized assessment of the outcome in patients with radicular back pain of the lumbar spine. The modified NASS questionnaire].

Background: The purpose of the study was to present a reliable instrument with easy application to assess the outcome and improvement of therapy in patients with radicular symptoms of the lumbar spine.

Methods: Data from patients who underwent microdiscectomy because of lumbar radicular symptoms were collected and analyzed and interviews were performed using the well-known North American Spine Society (NASS) lumbar spine questionnaire (17 items) before and after the intervention. In addition patient data including comorbidities were collected.

[Molecular characterization of epithelial ovarian borderline tumors with respect to clinical management and prognosis].

Objective: To analyze up-to-data knowledge in the field of molecular characterization of epithelial ovarian borderline tumors with respect to clinical management and prognosis.

Design: Review.

Setting: Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague, First Faculty of Medicine, and General Faculty Hospital, Prague.

Cell-mediated immunity in cervical cancer evolution.

Cell-mediated immunity (CMI) response to different antigens was examined in healthy women, in patients with cervical precancerous lesions, and in patients with cervical cancer. Cervical lesions were diagnosed by cytological (PAP) smears, from examination by colposcopy, and from "punch" biopsy material by histology. CMI response is related to specific processes in healthy and cancer cells.

[Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer].

Objective: To analyze loss of heterozygosity (LOH), loss of expression and somatic mutations of BRCA1, BRCA2 and p53 genes in sporadic epithelial ovarian cancer samples.

Design: Original paper.

Setting: Oncogynecologic center, Clinic of Obstetrics and gynecology, First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague.

[Detection of HPV DNA in lymph nodes in early stages cervical cancers].

Objective: Review recent knowledge concerning significance of detection of DNA HPV in regional lymph nodes in cervical cancer patients.

Type Of The Study: Literature review.

Setting: Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague.

Intermittent claudication caused by a hip joint ganglion.

A case report of a patient with unusual compressive syndrome is reported herein. A 27-year-old woman was referred to our hospital due to intermittent claudication in the left thigh and calf which gradually developed over the last five months. Angiography showed an atypical short occlusion of the external iliac artery.

[Contribution of neoadjuvant chemotherapy for operability of cancers of the uterine cervix].

Objective: To compare per-operative and post-operative morbidity in patients undergoing radical surgery for carcinoma of the uterine cervix after administration of a neoadjuvant chemotherapy, and for primarily small cervical tumour.

Type Of The Study: A retrospective case-control study.

Setting: Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague.

[Ductal approaches in mammary diagnostics].

Objective: Information about new possibilities of early diagnostics in mammary lesions.

Type Of Study: Review.

Setting: Gynecology-Obstetrics Clinic, 1st Medical Faculty and General Teaching Hospital, Prague.

[Glandular premalignant lesions of the uterine cervix].

Objective: Review of diagnostical and therapeutical methods in glandular premalignant lesions of the uterine cervix.

Design: Review article.

Setting: Department of Obstetrics and Gyneacology, 1st Medical Faculty, Charles University and General Faculty Hospital, Prague.

[Radical parametrectomy in women with invasive cervix cancer after previous simple hysterectomy].

Objective: Evaluate technique, indications and limits of surgical procedure in the treatment of cervical cancer diagnosed from uterus specimen from simple hysterectomy.

Design: Retrospective observational study, review of literature.

Settings: Department of Obstetrics and Gynecology, 1st Medical Faculty and General Faculty Hospital, Charles University, Prague, Czech Republic.

[Isolated lymphadenopathy as the first presentation of systemic mastocytosis--description of two cases].

Presented are two cases of systemic mastocytosis in 46- and 63-year-old women, where the correct diagnosis was established in randomly disclosed cervical respectively intraabdominal lymphadenopathy. Both cases lacked characteristic skin and systemic mast-cell mediator symptoms at the time of histologic diagnosis. The first case was classified as a indolent systemic mastocytosis without any proven genetic alteration, the second one met the criteria of aggressive systemic mastocytosis with eosinophilia, where the point mutation asp816val in c-kit gene was confirmed and the patient responded unexpectedly well to Gleevec.

[Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature].

Objective: To describe personnel experience with three unusual cases of low-grade adenosquamous carcinoma of the breast. Due to the aggressive course in two cases, the review of the literature does not concentrate on morphology and differential diagnosis only, but discuss overall biology of this lesion too.

Design: Three case reports.

Uterine necrosis after laparoscopic uterine vessel dissection for symptomatic fibroid--a case report.

Laparoscopic dissection of uterine vessels is a new minimally invasive method to treat symptomatic fibroids. A potential complication of uterine artery dissection is uterine necrosis. A woman with a large intramural fibroid underwent laparoscopic dissection of the uterine vessels using ultrasonic activated shears and three months later developed focal uterine necrosis requiring exploratory laparotomy and supracervical hysterectomy.

Diagnostic potential of neutrophil elastase inhibitor complex in the routine care of critically ill newborn infants.

Unlabelled: It has been suggested that determination of the neutrophil elastase alpha1-proteinase inhibitor complex (E-alpha1PI) improves the diagnosis of bacterial infection in newborns. We evaluated the use of E-alpha1PI measurements in 143 newborns, consecutively admitted to a tertiary intensive care unit, employing a new random access assay and a sampling procedure that minimises post-collection artefacts. The 95% range for noninfected newborns was 20-110 microg/l up to the 5th day of life and 20-85 microg/l thereafter.

[Granulosa cell tumor--clinical group and literature review].

Objective: To present a review of literature and to analyse a clinical retrospective series of patients with granulosa cell tumor.

Design: Retrospective study and review.

Setting: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Prague, Czech Republic.

[Cervical carcinoma during pregnancy].

Objective: To evaluate management and outcome of pregnant women with cervical carcinoma.

Design: Retrospective clinical study.

Setting: Institute for Mother and Child Care, Prague, Czech Republic.

Effect of collection and preprocessing methods on neutrophil elastase plasma concentrations.

Objectives: Elevated plasma levels of the elastase alpha 1-proteinase inhibitor complex (E-alpha 1 PI) have been proposed as a marker of bacterial infection and neutrophil activation. Liberation of elastase from neutrophils after collection of blood may cause falsely elevated results. Collection methods have not been validated for critically ill neonates and children.