Publications by authors named "Jannigje Rachel Kok"
Cell Mol Life Sci
August 2021
Article Synopsis
- Increasing evidence links DNA damage to neurodegenerative diseases like ALS, with high levels of DNA damage seen in both sporadic and familial cases, suggesting it may influence the disease's progression.
- Genetic mutations such as repeat expansions in the C9ORF72 gene are key contributors to DNA damage and instability, potentially leading to neuronal death and impacting the DNA damage response.
- Astrocytes are shown to contribute to motor neuron death in ALS, although the specific toxic factors involved remain largely unclear, highlighting the complexity of the disease's mechanisms.
