Publications by authors named "Janneke C van der Woude"
Background: Tofacitinib is an oral Janus kinase (JAK) inhibitor and is registered for the treatment of ulcerative colitis (UC). The effectiveness of tofacitinib has been evaluated up to 12 months of treatment.
Aim: The aim of this study was to assess the effectiveness and safety of 24 months of tofacitinib use in UC patients in the Netherlands.
Article Synopsis
- * Researchers analyzed data from two large studies, finding that male patients generally had earlier onset of CD and more severe disease locations, while female patients had more extraintestinal manifestations (EIMs).
- * Despite these differences in disease characteristics, the study concluded that there were no major variations in treatment management or healthcare costs between male and female IBD patients.
Aim: To determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability.
Methods: For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population.
Article Synopsis
- - The study focused on identifying predictors of nonadherence to medical therapy in patients with inflammatory bowel disease (IBD) by assessing various factors over 2.5 years using questionnaires and logistic regression analysis.
- - Among 2,612 patients (1,558 with Crohn's disease and 1,054 with ulcerative colitis), about 12.1% (CD) and 13.3% (UC) were found to be nonadherent to their medication, often involving specific treatments like mesalazine and budesonide.
- - Key predictors of future nonadherence included younger age at diagnosis, the presence of disease flares, feelings of anxiety or depression, and previous nonadherence, suggesting
Microbial metabolites may influence the metabolic integrity of intestinal epithelial cells and induce mucosal immune responses. Therefore, we investigated the effects of the microbial metabolites butyrate, iso-valerate, and ammonium on Caco-2 cells and macrophages. Barrier functioning was determined by measuring transepithelial electrical resistance and basolateral recoveries of metabolites.
View Article and Find Full Text PDFThe hypothesis was studied that intestinal microbial metabolites play a role in the pathogenesis of inflammatory bowel disease. For that purpose, an in vitro model of the colon was inoculated with fresh feces of six healthy individuals and eight inflammatory bowel disease patients. Samples were taken from the model over time to analyze metabolites from both saccharolytic and proteolytic fermentation.
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