Publications by authors named "Janne M Bibbe"
Ndufs4 knockout mice with isolated complex I deficiency engage a futile adaptive brain response.
Biochim Biophys Acta Proteins Proteom
January 2025
Article Synopsis
- Paediatric Leigh syndrome (LS) is a severe neurodegenerative disorder caused by mutations in the NDUFS4 gene, which affects mitochondrial function, and currently has no effective treatments.
- Researchers used whole-body Ndufs4 knockout (KO) mice to analyze differences in brain proteomes between these mice and wildtype mice, identifying variations across different brain regions.
- Findings highlighted reduced levels of critical mitochondrial components in specific brain areas and suggested that attempts to stimulate certain metabolic pathways could be harmful, prompting the need for new therapeutic strategies for managing LS.
G protein-coupled receptors (GPCRs) participate in most physiological processes and are important drug targets in many therapeutic areas. Recently, many GPCR X-ray structures became available, facilitating detailed studies of their sequence-structure-mobility-function relations. We show that the functional role of many conserved GPCR sequence motifs is to create weak spots in the transmembrane helices that provide the structural plasticity necessary for ligand binding and signaling.
View Article and Find Full Text PDFG-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signaling, drug action and allosteric modulation, but so far cover only 13% of nonolfactory receptors. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb ( http://www.
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