Connexin 43 upregulation in burns promotes burn conversion through spread of apoptotic death signals.

Background: Burn wounds continue to worsen after initial injury in a process known as burn conversion, which lasts about 3-5 days. It causes burn wounds to enlarge and deepen, leading to greater morbidity. Apoptosis is one of the factors contributing to the conversion of the zone of stasis into the zone of coagulation.

Biomechanical comparison of monocortical and bicortical plate fixation for rib fractures in a cadaveric model using a locking plate system.

Background: Surgical stabilization of rib fractures is an established form of treatment for complex rib fractures. Plate fixation with bicortical screws placement can cause injury to intra-thoracic organs and pleural irritation from protruding screw tips. The aim of this study is to compare the biomechanical properties of monocortical and bicortical plate fixation for rib fractures using a locking plate system.

Large animal models for long-segment tracheal reconstruction: a systematic review.

Background: The reconstruction of extensive tracheal defects is an unresolved problem. Despite decades of research, a reliable and practical substitute remains to be found. While there have been clinical reports of successful long-segment tracheal reconstruction, reproducibility and widespread applicability of these techniques have yet to be achieved.