Influence of stathmin 1 (STMN1) expression on neoangiogenesis in colorectal adenocarcinoma.

Stathmin1 is a microtubular regulatory protein. The expression disorders of this protein result in significant changes in cell migration, invasion, adhesion and colony formation in many malignant tumors. The aim of our research was to investigate the effects of Stathmin1 expression on neoangiogenesis in colorectal adenocarcinoma.

Clinical significance of Leptin receptor (LEPR) and Endoglin (CD105) expressions in colorectal adenocarcinoma.

Purpose: Carcinoma of the colon occurs quite more often in obese than in healthy people. The key molecule in the development of obesity is leptin, a product of Ob gene that expresses its effects through a specific receptor (LEPR), so our goal was to investigate the expression of LEPR in colorectal carcinoma and the association of their expression with neoangiogenesis, with local/regional and distant metastases and with tumor stage according to the Astler-Coller classification.

Methods: In the paraffin blocks taken from 75 patients treated for colorectal cancer, 3-4 μm thick cuts were made using routine hematoxylin-eosin (HE) and immunohistochemical ABC methods with anti-LEPR and anti-CD105 antibodies.