Publications by authors named "Janis Best-Lane"
Article Synopsis
- Epigenome-wide association studies (EWAS) analyze DNA methylation in whole blood to find genetic variations linked to traits, but it's uncertain if these variations occur in specific blood cell types.* -
- In this study, researchers collected various peripheral tissues and purified blood cell types, using advanced methods to profile DNA methylation across eight sample types from thirty individuals.* -
- They identified significant differences in DNA methylation levels and variability across different tissues, showing that whole blood methylation reflects influences from multiple cell types, which is important for understanding epigenetic associations in health research.*
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.
Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.
Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.
Article Synopsis
- Levosimendan is a drug that may help patients with sepsis by improving organ function, and a clinical trial was conducted to test its effectiveness compared to a placebo.
- The study included 516 patients, with no significant differences found in mean organ dysfunction scores or 28-day mortality rates between the levosimendan and placebo groups.
- However, patients receiving levosimendan had a lower success rate in weaning off mechanical ventilation and experienced more cases of a specific heart rhythm issue (supraventricular tachyarrhythmia) compared to those receiving placebo.
The aim of this study was to disentangle pervasive from situational antisocial behaviors using multiple informants, and to investigate their genetic and environmental etiologies in preadolescence and across time. Antisocial behaviors were assessed in 2,232 twins from the Environmental Risk (E-Risk) Longitudinal Twin Study at ages 5 and 12. Pervasive antisocial behaviors were defined as behaviors that mothers, teachers, interviewers, and twins themselves agreed on.
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