Publications by authors named "Janine S Aly"
Biol Psychiatry
January 2025
Article Synopsis
- - Chronic stress plays a significant role in mood and anxiety disorders, and previous studies suggest that vitamin B12 may help improve resilience against stress and depression, although the mechanisms behind this connection are still unclear.
- - Researchers used a mouse model to explore how vitamin B12 affects gene expression related to stress resilience, discovering that Ttr (transthyretin) is a key target for vitamin B12 and is linked to depression-like behaviors.
- - The study found that vitamin B12 reduces DNA methylation in the Ttr promoter, providing a causal link between vitamin B12, Ttr, and stress-related behaviors, which suggests that dietary interventions could be beneficial for mood disorders.
