Antipsychotics for children and young adults: a comparative effectiveness review.

Background And Objective: Despite increasing on-label and off-label use of antipsychotics, prescribing antipsychotics to children remains controversial due to uncertainty of their relative benefits and safety. We systematically reviewed the effectiveness and safety of first- (FGA) and second-generation antipsychotics (SGA) for patients aged ≤24 years with psychiatric and behavioral conditions.

Methods: We searched 10 databases from January 1987 to February 2011, gray literature, trial registries, and reference lists.

Systematic review: nonoperative and operative treatments for rotator cuff tears.

Background: Many approaches exist for managing rotator cuff tears.

Purpose: To compare the benefits and harms of nonoperative and operative interventions on clinically important outcomes in adults with rotator cuff tears.

Data Sources: 12 electronic databases (1990 to September 2009), gray literature, trial registries, and reference lists were searched.