The susceptibility of certain microbial strains to some imidazoline derivatives.

Imidazoline ring system is the structural element of many drugs which have different pharmacological spectrum of activity as ligands of the imidazoline receptor. Besides, from the literature data it follows that depending on the type of substituent certain derivatives of imidazoline may also show antimicrobial properties. The obtained compounds were tested for their potential antimicrobial activity.

Exclusion of antimicrobial activity of some analgesic active imidazo[2,1-c]triazines.

The purpose of this study was to exclude the potential antimicrobial activity of certain analgesic active imidazo[2,1-c]triazines. These compounds contain in their chemical structure potential pharmacophore formations and features similar to those present in morphine - like analgesics and opioid receptor agonists containing no basic nitrogen atom. These compounds showed significant antinociceptive activity on the central nervous system of the tested animals, correlated with very low toxicity value (LD50 value of above 2000 mg kg(-1) b.