Publications by authors named "Janina Gassen"
Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice.
Front Endocrinol (Lausanne)
March 2024
Article Synopsis
- Thyroid hormones (THs) are important for heart health, but their effects on older mice with existing heart issues remain unclear, especially in the context of conditions like hypertension and aging.
- A study found that manipulating TH levels in aged mice with heart damage (induced by transverse aortic constriction) showed minimal effects on heart function and structure, contrasting with significant changes seen in younger mice.
- The researchers noted altered expressions of certain genes related to TH metabolism and action in older mice, which might explain the reduced responsiveness of their hearts to thyroid hormone levels.
Thyroid hormones (TH) play a central role for cardiac function. TH influence heart rate and cardiac contractility, and altered thyroid function is associated with increased cardiovascular morbidity and mortality. The precise role of TH in onset and progression of heart failure still requires clarification.
View Article and Find Full Text PDFContext: Hypothyroidism impairs cardiovascular health and contributes to endothelial dysfunction with reduced vasodilation. How 3,5,3'-triiodothyronine (T3) and its receptors are involved in the regulation of vasomotion is not yet fully understood. In general, thyroid hormone receptors (TRs) either influence gene expression (canonical action) or rapidly activate intracellular signaling pathways (noncanonical action).
View Article and Find Full Text PDFAge and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses.
Exp Clin Endocrinol Diabetes
June 2020
Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly.
View Article and Find Full Text PDFNoncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
Proc Natl Acad Sci U S A
December 2017
Article Synopsis
- - Thyroid hormone (TH) and its receptors (TRs) can act through two pathways: the traditional type 1 pathway involves gene expression by binding to DNA, while a nontraditional type 3 pathway activates other cellular processes quickly without affecting gene expression.
- - Researchers created mutant mice that cannot bind DNA via TRs, which helped them discover that key physiological effects of TH, like heart rate and blood sugar levels, can still occur through the noncanonical signaling pathway.
- - The study demonstrates that noncanonical TR signaling has significant effects on metabolism and heart function, suggesting that thyroid hormone's actions are more complex than previously believed and not solely dependent on altering gene transcription.