Publications by Janina Enderle-Kukla

Publications by authors named "Janina Enderle-Kukla"

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The DNA-dependent protease AtWSS1A suppresses persistent double strand break formation during replication.

Leonie Hacker Niklas Capdeville Laura Feller Janina Enderle-Kukla Annika Dorn

New Phytol

February 2022

The protease WSS1A is an important factor in the repair of DNA-protein crosslinks in plants. Here we show that the loss of WSS1A leads to a reduction of 45S rDNA repeats and chromosomal fragmentation in Arabidopsis. Moreover, in the absence of any factor of the RTR (RECQ4A/TOP3α/RMI1/2) complex, which is involved in the dissolution of DNA replication intermediates, WSS1A becomes essential for viability.

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- Janina Enderle-Kukla's research primarily focuses on the role of the DNA-dependent protease AtWSS1A in the maintenance and repair of DNA, particularly concerning double strand breaks during plant replication processes.
- Her study, published in "New Phytol," demonstrates that the absence of WSS1A in Arabidopsis results in a significant decrease in 45S rDNA repeats and leads to chromosomal fragmentation, highlighting its crucial impact on genomic stability.
- The findings indicate that WSS1A is vital for viability in scenarios lacking components of the RTR complex, revealing its essential function in the DNA repair mechanisms under stress conditions.

Publications by authors named "Janina Enderle-Kukla"

The DNA-dependent protease AtWSS1A suppresses persistent double strand break formation during replication.

Synopsis of recent research by authors named "Janina Enderle-Kukla"