Publications by authors named "Janie Trinh"
Int J Biol Sci
February 2013
Article Synopsis
- Renal cell carcinoma (RCC) is highly resistant to traditional treatments like chemotherapy and immunotherapy, and its low response rates may be due to the tumor's escape strategies.
- Targeted therapies have improved patient outcomes, primarily by increasing the Th1-cytokine response (specifically IFNγ), which is important for slowing tumor growth.
- This study found that IFNγ inhibits the growth of certain RCC cell lines by altering L-arginine metabolism and promoting nitric oxide production, suggesting potential pathways for developing new combination therapies against RCC.
