Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and challenge.

Coccidiosis, caused by parasites, significantly impacts poultry farm economics and animal welfare. Beyond its direct impact on health, infection disrupts enteric microbial populations leading to dysbiosis and increases vulnerability to secondary diseases such as necrotic enteritis, caused by . The impact of infection or anticoccidial vaccination on host gastrointestinal phenotypes and enteric microbiota remains understudied.

investigation of the genus type VI secretion system reveals genetic diversity in organization and putative effectors.

Bacterial type VI secretion systems (T6SSs) are contractile nanomachines that deliver proteinic substrates into target prokaryotic or eukaryotic cells and the surrounding milieu. The genus encompasses 39 recognized species and 13 subspecies, with many belonging to a group known as ‘emerging pathogens’. Within , seven species have been identified to harbour a complete T6SS cluster but have yet to be comparatively assessed.

Effects of the Lipid Profile, Type 2 Diabetes and Medication on the Metabolic Syndrome-Associated Gut Microbiome.

Metabolic syndrome (MetSyn) is a major health problem affecting approximately 25% of the worldwide population. Since the gut microbiota is highly connected to the host metabolism, several recent studies have emerged to characterize the role of the microbiome in MetSyn development and progression. To this end, our study aimed to identify the microbiome patterns which distinguish MetSyn from type 2 diabetes mellitus (T2DM).

Corrigendum: Bioinformatic Analysis of the Type VI Secretion System and Effector Prediction.

[This corrects the article DOI: 10.3389/fmicb.2021.

Bioinformatic Analysis of the Type VI Secretion System and Effector Prediction.

The Type VI Secretion System (T6SS) has important roles relating to bacterial antagonism, subversion of host cells, and niche colonisation. is one of the leading bacterial causes of human gastroenteritis worldwide and is a commensal coloniser of birds. Although recently discovered, the T6SS biological functions and identities of its effectors are still poorly defined in .

The Type VI Secretion System Enhances the Oxidative Stress Response and Host Colonization.

The role of the Type VI secretion system (T6SS) in is poorly understood despite an increasing prevalence of the T6SS in recent isolates in humans and chickens. The T6SS is a contractile secretion machinery capable of delivering effectors that can play a role in host colonization and niche establishment. During host colonization, is exposed to oxidative stress in the host gastrointestinal tract, and in other bacteria the T6SS has been linked with the oxidative stress response.