Publications by authors named "Janie Liaw"

Coccidiosis, caused by parasites, significantly impacts poultry farm economics and animal welfare. Beyond its direct impact on health, infection disrupts enteric microbial populations leading to dysbiosis and increases vulnerability to secondary diseases such as necrotic enteritis, caused by . The impact of infection or anticoccidial vaccination on host gastrointestinal phenotypes and enteric microbiota remains understudied.

View Article and Find Full Text PDF

Bacterial type VI secretion systems (T6SSs) are contractile nanomachines that deliver proteinic substrates into target prokaryotic or eukaryotic cells and the surrounding milieu. The genus encompasses 39 recognized species and 13 subspecies, with many belonging to a group known as ‘emerging pathogens’. Within , seven species have been identified to harbour a complete T6SS cluster but have yet to be comparatively assessed.

View Article and Find Full Text PDF

Metabolic syndrome (MetSyn) is a major health problem affecting approximately 25% of the worldwide population. Since the gut microbiota is highly connected to the host metabolism, several recent studies have emerged to characterize the role of the microbiome in MetSyn development and progression. To this end, our study aimed to identify the microbiome patterns which distinguish MetSyn from type 2 diabetes mellitus (T2DM).

View Article and Find Full Text PDF

The Type VI Secretion System (T6SS) has important roles relating to bacterial antagonism, subversion of host cells, and niche colonisation. is one of the leading bacterial causes of human gastroenteritis worldwide and is a commensal coloniser of birds. Although recently discovered, the T6SS biological functions and identities of its effectors are still poorly defined in .

View Article and Find Full Text PDF

The role of the Type VI secretion system (T6SS) in is poorly understood despite an increasing prevalence of the T6SS in recent isolates in humans and chickens. The T6SS is a contractile secretion machinery capable of delivering effectors that can play a role in host colonization and niche establishment. During host colonization, is exposed to oxidative stress in the host gastrointestinal tract, and in other bacteria the T6SS has been linked with the oxidative stress response.

View Article and Find Full Text PDF
Article Synopsis
  • Outer membrane vesicles (OMVs) play a critical role in virulence for certain pathogens by carrying harmful proteins like toxins and proteases, especially because they lack traditional secretion systems.
  • The study found that the presence of sodium taurocholate (ST), a bile salt, stimulates OMV production through an unexplored mechanism and that the maintenance of lipid asymmetry (MLA) pathway is involved in this process.
  • Mutating the MLA pathway increased OMV production, and while ST enhanced production and reduced OMV size in wild-type strains, it did not impact the mutant strain, revealing how dietary factors and gut signals may influence pathogen behavior.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session5vkqt0gsaq2hvrd77ras31u6o6hjodcf): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once