Pediatric oncology sedation trial (POST): A double-blind randomized study.

Background: There is limited evidence to support the use of an anti-emetic with the administration of intra-thecal chemotherapy. Nor is there adequate clarity on analgesic strategies for children with cancer undergoing painful procedures.

Procedures: A double-blind, randomized, placebo-controlled, factorial trial was performed in children with acute lymphoblastic leukemia undergoing combined bone marrow aspirations and lumbar punctures during maintenance therapy.