Publications by authors named "Janie Johnson"
Article Synopsis
- Fundamental frequency ( ) affects social perceptions, with low male frequencies enhancing perceptions of men's strength and status, especially in societies with high homicide rates and competitive environments.
- On the other hand, high female frequencies made women seem more flirtatious, particularly in societies with lower relational mobility and higher fears of relationship threats.
- The study shows that the impact of on social perceptions varies significantly based on socioecological factors related to competition for status and mates across different cultures.
Background: Atherosclerosis preferentially occurs in arterial regions of disturbed blood flow, and stable flow (s-flow) protects against atherosclerosis by incompletely understood mechanisms.
Methods: Our single-cell RNA-sequencing data using the mouse partial carotid ligation model was reanalyzed, which identified Heart-of-glass 1 (HEG1) as an s-flow-induced gene. HEG1 expression was studied by immunostaining, quantitive polymerase chain reaction, hybridization chain reaction, and Western blot in mouse arteries, human aortic endothelial cells (HAECs), and human coronary arteries.
Atherosclerosis is a chronic inflammatory disease and occurs preferentially in arterial regions exposed to disturbed blood flow (d-flow) while the stable flow (s-flow) regions are spared. D-flow induces endothelial inflammation and atherosclerosis by regulating endothelial gene expression partly through the flow-sensitive transcription factors (FSTFs). Most FSTFs, including the well-known Kruppel-like factors KLF2 and KLF4, have been identified from studies using cultured endothelial cells (ECs).
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