Impact of antibiotic susceptibility reporting on broad spectrum antibiotic use in serratia and morganella bacteremia.

To minimize broad-spectrum antibiotic use, our microbiology laboratory changed antibiotic susceptibility reporting for AmpC-beta-lactamase producing and in blood cultures to include results of narrow spectrum 3rd generation cephalosporins. We assessed the impact of this change on broad-spectrum antibiotic use and clinical outcomes. All adult patients with or in blood culture 2 years pre- and post-change of susceptibility reporting were retrospectively reviewed.

Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains.

Meropenem and piperacillin are two commonly prescribed antibiotics in critically ill surgical patients. To date, the pharmacokinetics of these antibiotics in the presence of indwelling abdominal surgical drains is poorly defined. This was a prospective pharmacokinetic study of meropenem and piperacillin.