Publications by authors named "Janice Roth"
Article Synopsis
- - This study compares the outcomes of early versus delayed pars plana vitrectomy (PPV) in patients experiencing their first vitreous hemorrhage (VH) due to proliferative diabetic retinopathy (PDR) at Moorfields Eye Hospital from 2014 to 2016, excluding patients with specific eye conditions.
- - Patients were categorized into two groups: early PPV (within 6 weeks) and delayed PPV (after 6 weeks), with data collected on visual acuity and complications at baseline and 12 months post-surgery.
- - Results indicated that the early PPV group had significantly better visual acuity and fewer serious complications compared to the delayed group, highlighting the benefits of earlier intervention.
Article Synopsis
- The study evaluates the pharmacokinetics, safety, and optimal dosages of intravitreal agents in eyes filled with silicone oil, while addressing challenges of treatment administration.
- Findings suggest that while anti-VEGF agents have similar half-lives in silicone oil-filled eyes, most evidence is derived from case reports and small studies, with standard dosages recommended for drugs like bevacizumab being the most supported.
- The research emphasizes the importance of close monitoring for side effects, with specific guidance on the use of various intravitreal medications, including steroids, antivirals, and antibiotics.
Artificial intelligence derived large language model in decision-making process in uveitis.
Int J Retina Vitreous
September 2024
Background: Uveitis is the ophthalmic subfield dealing with a broad range of intraocular inflammatory diseases. With the raising importance of LLM such as ChatGPT and their potential use in the medical field, this research explores the strengths and weaknesses of its applicability in the subfield of uveitis.
Methods: A series of highly clinically relevant questions were asked three consecutive times (attempts 1, 2 and 3) of the LLM regarding current uveitis cases.
Background: To describe clinical features, risk factors and outcomes of patients with diagnosis of rare spontaneous suprachoroidal haemorrhage (SSCH) over a 20-year period from a tertiary eye unit.
Methods: Retrospective, observational case-series of patients with SSCH, defined as SCH without a known cause at diagnosis. Variables analysed included age, gender, ethnicity, systemic and ocular comorbidities, systemic medication, initial and final best corrected visual acuity (BCVA), clinical features, management and follow-up.
Purpose: To evaluate the clinical efficacy and safety of asynchronous virtual post-operative assessments following vitreoretinal surgery and procedures compared to traditional face-to-face assessments in a high-volume tertiary eye centre.
Methods: Prospective comparative clinical series study of patients who had undergone vitreoretinal surgery or post-laser retinopexy. Patients received both virtual and face-to-face assessments.
Introduction: Age-related macular degeneration (AMD) affects millions of people globally, leading to a surge in online research of putative diagnoses, causing potential misinformation and anxiety in patients and their parents. This study explores the efficacy of artificial intelligence-derived large language models (LLMs) like in addressing AMD patients' questions.
Methods: ChatGPT 3.
Purpose: To describe and evaluate demographics, clinical features, prognostic factors, rate of success of surgery, incidence, and visual outcomes in patients with a late recurrence of rhegmatogenous retinal detachment over a 10-year period at a large tertiary referral eye center.
Methods: A retrospective, observational case series of patients with late recurrence of retinal detachment, defined as redetachment after at least six months of total reattachment in non-proliferative vitreoretinopathy (PVR) rhegmatogenous retinal detachment, after pars plana vitrectomy (PPV) surgery with gas tamponade.
Results: Thirty-nine patients had a late recurrence of rhegmatogenous retinal detachment of 16,396 rhegmatogenous retinal detachment operations.
Purpose: To describe and evaluate demographic, clinical features, prognostic factors, and rate of success of surgery and visual outcomes in patients with late presentation of retinal detachment.
Methods: A retrospective, comparative, observational case series of patients with late presentation retinal detachment, defined as retinal detachment with the loss of central vision for 4 weeks or more, over a period of 12 months.
Results: The mean of onset of central visual loss was 12.
Aflibercept is a fully human recombinant fusion protein that includes the second domain of human VEGF receptor 1 and the third domain of human VEGF receptor 2. Despite the important role played by VEGF in maintaining the physiological condition of the retina under normal conditions, dysregulation of VEGF can result in pathological alterations including hyperpermeability of the retinal capillaries and migration and proliferation of retinal endothelial cells. Over the years, a number of studies have evaluated the use of intravitreal aflibercept in different retinal diseases.
View Article and Find Full Text PDFPurpose: To report a case of vascularized idiopathic epiretinal membrane including the multimodal imaging.
Methods: Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, optical coherence tomography angiography, and fluorescein angiography.
Results: Sixty-three-year-old woman with a previous rhegmatogenous retinal detachment (RRD) who presented with an asymptomatic idiopathic neovascular complex below an epiretinal membrane.
Background: Percutaneous closure of the patent foramen ovale (PFO) is a widely used procedure in patients with paradoxical embolism. Whether or not implantation of a PFO closure device alters cardiac chamber anatomy and in turn affects valvular function is unclear.
Methods: Out of 334 patients who underwent PFO closure between 2002 and 2010, a total of 196 received an Amplatzer septal occluder and were retrospectively analyzed.