Longitudinal assessment of short-term memory deterioration in a logopenic variant primary progressive aphasia with post-mortem confirmed Alzheimer's Disease pathology.

In the field of dementia research, there are reports of neurodegenerative cases with a focal loss of language, termed primary progressive aphasia (PPA). Currently, this condition has been further sub-classified, with the most recent sub-type dubbed logopenic variant (PPA-LV). As yet, there remains somewhat limited evaluation of the characteristics of this condition, with no studies providing longitudinal assessment accompanied by post-mortem examination.

Eighteen years on: What next for the PALPA?

The Psycholinguistic Assessments of Language Processing Abilities (PALPA) is a battery of tests designed to assess language processing abilities in individuals with acquired aphasia. Published in 1992, the battery was well-received by both clinicians and researchers, yet no revised version has been published to date. In this paper, we examine contemporary usage of the PALPA in both clinical and research settings, to inform decisions regarding future developments of the resource.

Positive and negative emotion enhances the processing of famous faces in a semantic judgment task.

Previous work has consistently reported a facilitatory influence of positive emotion in face recognition (e.g., D'Argembeau, Van der Linden, Comblain, & Etienne, 2003).

Visuoperceptual deficits in letter-by-letter reading?

A longstanding and controversial issue concerns the underlying mechanisms that give rise to letter-by-letter (LBL) reading: while some researchers propose a prelexical, perceptual basis for the disorder, others postulate a postlexical, linguistic source for the problem. To examine the nature of the deficit underlying LBL reading, in three experiments, we compare the performance of seven LBL readers, matched control participants and one brain-damaged patient, OL, with no reading impairment. Experiment 1 revealed that the LBL patients were impaired, relative to the controls and to OL, on a same/different matching task using checkerboards of black and white squares.

Dysgraphia in dementia: a systematic investigation of graphemic buffer features in a case series.

In this paper we report findings from a systematic investigation of spelling performance in three patients - PR, RH and AC - who despite their different medical diagnoses showed a very consistent pattern of dysgraphia, more typical of graphemic buffer disorder. Systematic investigation of the features characteristic of this disorder in Study 1 confirmed the presence of length effects in spelling, classic errors (i.e.

Longitudinal assessment of language and memory impairments in pathologically confirmed cortico-basal ganglionic degeneration.

We report a longitudinal case study (patient EP) of histologically confirmed cortico-basal ganglionic degeneration (CBD) who presented with non-fluent progressive aphasia (NFPA). While NFPA has been documented in clinical descriptions of other reports of CBD, details are often limited and the majority of studies are cross-sectional in nature. The present study conducted detailed longitudinal assessment with EP over a period of two years that revealed substantial impairments of episodic memory, semantic memory, naming and particular aspects of reading and spelling.

Does maintenance of colour categories rely on language? Evidence to the contrary from a case of semantic dementia.

Recent neuropsychological evidence, supporting a strong version of Whorfian principles of linguistic relativity, has reinvigorated debate about the role of language in colour categorisation. This paper questions the methodology used in this research and uses a novel approach to examine the unique contribution of language to categorisation behaviour. Results of three investigations are reported.

Neuropsychological and psychiatric profiles in acute encephalitis in adults.

Acute encephalitis is an inflammation of brain tissue that can result from activity in the central nervous system (CNS) of a number of viruses. Although the neurological and psychiatric effects of encephalitis in the acute phase of the illness are well-known (Caroff, Mann, Gliatto, Sullivan, & Campbell, 2001), larger scale studies of the pattern of neuropsychological and psychiatric impairment following recovery from the acute inflammatory phase are less apparent. This paper reports the results of neuropsychological testing with a range of standardised cognitive measures in a case series of long-term post-acute participants.

Phonological dyslexia and phonological impairment: an exception to the rule?

The condition known as phonological dyslexia involves very poor reading of non-words, with otherwise good word reading performance [e.g. Derouesné & Beauvois, 1979; Sartori, G.

Selective preservation of memory for people in the context of semantic memory disorder: patterns of association and dissociation.

A number of single cases in the literature demonstrate that person-specific semantic knowledge can be selectively impaired after acquired brain damage compared with that of object categories. However, there has been little unequivocal evidence for the reverse dissociation, selective preservation of person-specific semantic knowledge. Recently, three case studies have been published which provide support for the claim that such knowledge can be selectively preserved [Kay, J.

"Deep" language disorders in nonfluent progressive Aphasia: an evaluation of the "summation" account of semantic errors across language production tasks.

This study focuses on the pattern of impairments seen in a new case KT, diagnosed with nonfluent progressive aphasia (NFPA), a degenerative disorder of language production. A systematic examination of KT's performance on a wide range of language production tasks (i.e.

Phonetic and phonological analysis of progressive speech degeneration: a case study.

In this paper we report on an adult male participant with a rare form of progressive speech degeneration. We present acoustic phonetic data on his vowel and consonant production, and describe his prosody and syllable structure. We suggest possible phonological analyses of his speech, concluding that a gestural approach to phonology best characterizes his speech production and its degeneration.

Biographical knowledge: modality-specific or modality-neutral?

A number of patients have been reported who produce more semantic information in response to faces than to names, and vice versa (e.g., Eslinger et al.

Evidence for the involvement of a nonlexical route in the repetition of familiar words: A comparison of single and dual route models of auditory repetition.

In this paper, we attempt to simulate the picture naming and auditory repetition performance of two patients reported by Hanley, Kay, and Edwards (2002), who were matched for picture naming score but who differed significantly in their ability to repeat familiar words. In Experiment 1, we demonstrate that the model of naming and repetition put forward by Foygel and Dell (2000) is better able to accommodate this pattern of performance than the model put forward by Dell, Schwartz, Martin, Saffran, and Gagnon (1997). Nevertheless, Foygel and Dell's model underpredicted the repetition performance of both patients.

An evaluation of statistical procedures for comparing an individual's performance with that of a group of controls.

The single case methodology that is widely used in cognitive neuropsychology often requires a comparison of data from a single individual (the patient) with that from a group of controls, in order to ascertain whether the patient's mean score can be viewed as significantly different from that of controls. This article reviews methods that have been used to deal with such data. Although Analysis of Variance (ANOVA) provides one possible solution of comparing group means, unequal group sizes and differences in variability between patient and controls can violate the assumptions of the test.

Anomia for common names and geographical names with preserved retrieval of names of people: a semantic memory disorder.

This paper describes the case of an anomic patient (FH) who is impaired at naming pictures of objects but has no difficulties in recalling the names of familiar people. Even though his performance on McKenna's (1997) Category Specific Naming Test was at the first percentile, he consistently recalled the names of familiar people as successfully as controls. It is argued that the pattern of performance displayed by FH represents a much clearer double dissociation with proper name anomia than any case previously reported (Cipolotti et al.

Imageability effects, phonological errors, and the relationship between auditory repetition and picture naming: Implications for models of auditory repetition.

Hanley and Kay (1997) reported the case of a patient (PS) who showed effects of imageability on tests of auditory repetition, but whose errors were phonological rather than semantic. They argued that this pattern of performance could be explained in terms of a partial impairment to both lexical and nonlexical repetition routes so long as some interaction between the two routes was allowed, consistent with Hillis and Caramazza's (1991) "summation" hypothesis. The present paper investigates the performance of a new patient (MF) who also makes a large number of phonological errors when repeating words of low imageability.

Preservation of memory for people in semantic memory disorder: Further category-specific semantic dissociation.

ML, a 70-year-old right-handed woman, presented with a history of semantic memory difficulties and a profound anomia affecting both proper nouns and common nouns following a left-hemisphere CVA some years earlier. She was found to show a striking contrast between her ability to make fine-grained semantic distinctions between objects and animals, on the one hand, and famous faces and names, on the other. Although she was impaired on a series of picture and word semantic comprehension tests when the stimuli consisted of exemplars of object and animal categories, her performance was intact when the materials comprised famous faces and names, suggesting a dissociation between the representation of person-specific knowledge and other categories of semantic information.

NOTE: DOES THE GRAPHEMIC BUFFER PLAY A ROLE IN READING?

In this paper, we investigate the reading performance of a patient previously reported as having an impairment at the level of the graphemic buffer (Kay & Hanley, 1994). Despite his spelling problems, this patient is good at reading familiar words, at reading nonwords, and at written lexical decision. This pattern of performance is discussed with respect to Caramazza, Capasso, and Miceli's (1996) recent claim that damage to the graphemic buffer leads to a problem in reading that will be obvious especially when the patient is asked to read nonwords.