Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab')2 antivenoms.

Background: Envenomation by pit vipers is associated with coagulation disorders including hypofibrinogenemia and thrombocytopenia. These abnormalities correct following antivenom treatment during the acute phase of the disease. Delayed or recurrent coagulation abnormalities have been reported following use of Fab antivenom, resulting in risk of hemorrhage or death.

Safety of intravenous equine F(ab')2: insights following clinical trials involving 1534 recipients of scorpion antivenom.

Introduction: The technology of antivenom production has gradually changed since the earliest production of antisera around the turn of the 20th century. Use of early antisera was associated with frequent acute adverse reactions and serum sickness. New F(ab')2 products, manufactured using pepsin degradation of immunoglobulin together with precipitation of unwanted protein and albumin serum fractions, should in concept cause fewer immune reactions in clinical use.

Are patients with breast cancer satisfied with their decision making? A pilot study.

This pilot study measured participants' comfort with their decision making to have a lumpectomy and radiation or total mastectomy to treat their breast cancer. Findings showed 87% of the patients believed they had made an informed choice and were satisfied with their decision making regarding their surgical procedure selection.

Are patients with breast cancer satisfied with their decision making?: a comparison over time.

Choosing between lumpectomy with radiation versus mastectomy is difficult for women with early-stage breast cancer, and doubt can decrease women's confidence and satisfaction. As a result, the current study surveyed satisfaction before and after surgery in a convenience sample of women with early-stage breast cancer from a single practice. All women received either total mastectomy or lumpectomy plus radiation based on their informed choice of surgical options.