Publications by authors named "Janhvi Mahesh Dhongdi"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with limited treatment options, and TMZ, the current standard drug, has been criticized for its minimal impact on survival and frequent relapses.
- The study investigates new phenothiazine-based inhibitors targeting Tousled-like kinase-1 (TLK1), which is overexpressed in GBM and contributes to DNA repair, potentially enhancing the efficacy of TMZ.
- Results show that the combination of phenothiazines with TMZ reduces tumor growth and invasion in MGMT-deficient cells, while also increasing DNA damage, suggesting TLK1 inhibitors could be a promising new treatment for GBM patients.
