Sex difference in kidney electrolyte transport II: impact of K intake on thiazide-sensitive cation excretion in male and female mice.

We studied sex differences in response to high K (HK) intake on thiazide-sensitive cation (Na and K) excretion in wild-type (WT) and ANG II receptor subtype 1a (ATR) knockout (KO) mice. Renal clearance experiments were performed to examine Na-Cl cotransporter (NCC) activity on mice fed with control and HK (5% KCl, 7 days) diets. Hydrochlorothiazide (HCTZ)-induced changes in urine volume, glomerular filtration rate, absolute Na and K excretion, and fractional excretion were compared.