First and second pregnancy outcomes in women with class III obesity: An observational cohort study.

Introduction: Class III obesity (BMI ≥ 40 kg/m) during pregnancy predisposes mother and offspring to a range of adverse pregnancy complications and outcomes. Risk profiles vary between pregnancies and are affected by interpregnancy weight gain. We evaluated the risk of adverse outcomes in women with BMI ≥ 40 kg/m in first and second pregnancies, and the impact of interpregnancy weight change on this risk.