Survey of Human Chromosome 21 Gene Expression Effects on Early Development in .

Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS), one of the most genetically complex conditions compatible with human survival. Assessment of the physiological consequences of dosage-driven overexpression of individual Hsa21 genes during early embryogenesis and the resulting contributions to DS pathology in mammals are not tractable in a systematic way. A recent study looked at loss-of-function of a subset of orthologs of Hsa21 genes and identified ten candidates with behavioral phenotypes, but the equivalent over-expression experiment has not been done.

Rhabdomyolysis in a patient treated with linezolid for extensively drug-resistant tuberculosis.

Prolonged use of linezolid was temporally and mechanistically associated with rhabdomyolysis in a patient being treated for extensively drug-resistant tuberculosis. Careful laboratory monitoring of such subjects is important during prolonged linezolid therapy.