Publications by authors named "Janeth Santiago-Cruz"
Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico.
Areli Martínez-Gamboa María Dolores Niembro-Ortega Pedro Torres-González Janeth Santiago-Cruz Nancy Guadalupe Velázquez-Zavala
PLoS Negl Trop Dis
March 2021
Article Synopsis
- A multicenter study in Mexico aimed to evaluate the effectiveness of various tests for diagnosing progressive disseminated histoplasmosis (PDH) in individuals living with HIV.
- The study involved 415 participants and compared the diagnostic accuracy of urine antigen tests and nested PCR methods, confirming PDH through blood, tissue cultures, or histopathology.
- Results showed that the cHGEI IMMY test had the highest sensitivity (91.3%) among the urine tests, while nested PCR tests demonstrated varying sensitivity levels, indicating different diagnostic strengths for identifying this serious infection.
Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.
Pedro Torres-González María Dolores Niembro-Ortega Areli Martínez-Gamboa Víctor Hugo Ahumada-Topete Jaime Andrade-Villanueva Janeth Santiago-Cruz
PLoS Negl Trop Dis
November 2018
Article Synopsis
- The study evaluates the diagnostic accuracy of the ALPHA Histoplasma urine antigen (HUAg) test for detecting progressive disseminated histoplasmosis (PDH) in HIV patients, particularly in Mexico.
- In a sample of 288 patients suspected of having PDH, the ALPHA-HUAg showed a sensitivity of 67.1% and a high specificity of 97.5%, indicating it is fairly good at confirming PDH but may miss some cases.
- Despite its high specificity, the low sensitivity means that ALPHA-HUAg can't be solely relied on for diagnosis, and a culture-based approach is recommended to account for potential co-infections.