Introduction: In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with Gomes stem bark.
Methods And Materials: Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In total, 116 endophytic fungi strains were isolated from 90 fragments (64.
Endophytic fungi were isolated from healthy leaves of Indigofera suffruticosa Miller, a medicinal plant found in Brazil which is used in folk medicine to treat various diseases. Among 65 endophytic fungi isolated, 18 fungi showed activity against at least one tested microorganism in preliminary screening, and the best results were obtained with Nigrospora sphaerica (URM-6060) and Pestalotiopsis maculans (URM-6061). After fermentation in liquid media and in semisolid media, only N.
View Article and Find Full Text PDFThis study evaluated the antimicrobial and hemolytic activities and phytochemical constituents of hydroalcoholic extract and its fractions from Buchenavia tetraphylla leaves. Cyclohexane (BTCF), ethyl acetate (BTEF), and n-butanol-soluble (BTSBF) and non-soluble (BTNBF) fractions were obtained from a liquid-liquid partition of hydroalcoholic extract (BTHE) from B. tetraphylla leaves.
View Article and Find Full Text PDFStreptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to produce bioactive secondary metabolites, such as antifungals, antivirals, antitumorals, anti-hypertensives, immunosuppressants, and especially antibiotics.
View Article and Find Full Text PDFThis study evaluated the antibacterial activity of Anadenanthera colubrina, Libidibia ferrea and Pityrocarpa moniliformis fruit extracts against clinical strains of Staphylococcus aureus. The samples were active for all S. aureus strains (minimum inhibitory concentration: 0.
View Article and Find Full Text PDFPharm Biol
February 2012
Context: The idea that many commonly used medicinal plants may lead to the discovery of new drugs has encouraged the study of local knowledge of these resources.
Objective: An ethnobotanical survey of species traditionally used for the treatment of infectious diseases was undertaken in two areas of northeastern Brazil: one in the Caatinga (dry forest) and another in the Atlantic Forest (humid forest).
Materials: Initially, diffusion tests using paper disks and subsequently, for extracts presenting significant results (inhibition halos above 15 mm), minimum inhibitory concentrations were determined.
In recent years, biosurfactants have attracted attention because of their low toxicity, high biodegradability, and good ecological acceptability. However, their production in submerged liquid culture is hampered by the severe foaming that occurs. Solid-state cultivation can avoid this problem.
View Article and Find Full Text PDFTwo series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and 1H-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice.
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