Clinical Characteristics in Patients with Triple Negative Breast Cancer.

Purpose: The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis.

Methods: Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016.

Results: Out of a total of 1964 patients, 190 (10%) patients had TNBC.

Nicotine nasal spray as an adjuvant analgesic for third molar surgery.

Purpose: To determine the efficacy of preoperatively administered nicotine nasal spray (3 mg) for analgesia after third molar (TM) surgery.

Materials And Methods: A single-center, prospective, randomized, double-blind, crossover trial was conducted. The study population consisted of 20 nonsmoking patients referred to the Department of Oral and Maxillofacial Surgery of Columbia University College of Dental Medicine for extraction of all 4 TMs.

Anesthesia matters: patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane.

Background: Preclinical studies have suggested that some volatile anesthetics induce a hyperalgesic state that may be secondary to nicotinic inhibition. A previous trial of treatment with nicotine nasal spray demonstrated postoperative analgesia in women anesthetized with isoflurane. To determine whether the effect of nicotine was reversing hyperalgesia induced by isoflurane, or simply acting as an analgesic, we studied the effect of nicotine on postoperative pain in women anesthetized with isoflurane or propofol, with fentanyl.