Publications by authors named "Janet Ren Chao"
Article Synopsis
- The use of energy-based devices in cosmetic treatments for higher Fitzpatrick skin types poses risks like hyperpigmentation and scarring, but advancements have made safer options available.
- Noninvasive treatments like radiofrequency (RF) skin tightening and microfocused ultrasound (MFUS) effectively improve skin laxity and stimulate collagen production without excessive heat, making them suitable for darker skin tones.
- Fractional laser resurfacing, particularly nonablative lasers that target water, along with RF microneedling and the short-pulse Nd:YAG laser, have shown promising results in treating various skin concerns in patients with Fitzpatrick skin types 4 to 6.
Article Synopsis
- Age-related hearing loss (ARHL) is a neurodegenerative condition linked to aging, influenced by biological factors like aging, sex, and atherosclerosis.
- In a study, ApoE knockout male mice were given a western diet for 16 weeks, and their auditory response, lipid levels, and atherosclerotic plaques were analyzed to understand the mechanisms of ARHL influenced by atherosclerosis.
- Findings showed a significant increase in hearing loss and a correlation between ABR thresholds and atherosclerotic plaque area, suggesting that increased reactive oxygen species and apoptosis in cochlear neurons contribute to the onset of hearing loss in these mice, making them a valuable model for ARHL research.
For a minimally invasive approach to access the facial nerve, we designed an extended epitympanotomy via a transmastoid approach that has proven useful in cases of traumatic facial nerve palsy and pre-cholesteatoma. To evaluate the surgical exposure through an extended epitympanotomy, six patients with traumatic facial nerve palsy were enrolled in this study. The same surgical technique was used in all patients.
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- The study mapped the central nervous system vasculature in six different laboratory animals: Korean wild mouse, C57BL/6J mouse, F344 rat, Mongolian gerbil, Syrian hamsters, and guinea pigs, highlighting their anatomical differences.
- Alcian blue reagent was used to stain blood vessels, revealing variations in structures like the anterior cerebral arteries and the hypophyseal portal system across species.
- The findings provide valuable images and anatomical data that can aid researchers in designing experimental models and surgical approaches in future studies.
Article Synopsis
- The study explored how tissue clearing techniques can be applied to otology by using a perfusion system to visualize the vascular anatomy of temporal bones in various lab animal species.
- Six species, including mice and guinea pigs, were examined using a combination of Alcian blue dye and paraformaldehyde for vital staining.
- The research revealed distinct anatomical features and patterns, such as the unique distribution of melanocytes in the cochlea, which could aid fellow researchers in formulating new hypotheses and experimental designs.
The original version of this Article contained errors in Figs. 5 and 6. In Fig.
View Article and Find Full Text PDFAlthough three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution.
View Article and Find Full Text PDFObjective: Early prediction of therapeutic outcomes could reduce exposure to ineffective treatments and optimize clinical outcomes. However, none of the known otologic predictors is amenable to therapeutic intervention for idiopathic sudden sensorineural hearing loss (ISSNHL). The aims of this study were to investigate psychological stress as a potential predictor to discriminate outcomes in ISSNHL.
View Article and Find Full Text PDFThis case report describes the use a new flexible robotic system in otolaryngology, the FlexRobot for cricopharyngeal myotomy in cadaver dissections, and for the treatment of a patient with esophageal stenosis and secondary dysphagia and dysphonia. The Flexrobot facilitates access to the hypopharynx with increased proximity to the surgical field and improved optics, allowing more exact dilatation and injection in our patient. It also would allow surgeons to reach deep inside the cavity of the hypopharynx into anatomical regions that are typically inaccessible without an open approach, as shown in our cadaveric procedure, where full exposure of the posterior aspect of the cricopharyngeus and isolation of the muscle belly were achieved.
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- The study investigates the evolution of topics in otology literature over the years, utilizing key terms related to diagnosis and therapy through PubMed search.
- There has been a noticeable rise in research focus on age-related hearing loss, speech discrimination, and cochlear implantation in recent years.
- This bibliometric analysis highlights changing research trends in otology, providing insight for future studies in the field of Otorhinolaryngology Head and Neck Surgery.
Article Synopsis
- The study aimed to analyze and compare the vascular and related anatomy of the cervical and facial regions in five different murine species for better research applications in human disease.
- Adult male mice, rats, gerbils, hamsters, and guinea pigs were used, with their vascular systems stained using Trypan Blue to visualize anatomy in the head and neck.
- Findings highlighted unique anatomical features like the Mongolian Gerbil's symmetrical carotid origins and the hamster's large submandibular gland, providing valuable insights for researchers to choose suitable animal models for disease studies.
Objectives: To reduce the mastoid cavity-associated problems secondary to canal wall down mastoidectomy, we designed a new surgical procedure that includes canal wall reconstruction using free-floating cartilages and double musculoperiosteal flaps.
Study Design: Retrospective study.
Materials And Methods: Thirty-three patients were enrolled in this study.
Hydrocolloid dressings have been developed for many types of wound healing. In particular, dressing is a critical component in the successful recover of burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally, silk fibroin is the safest material for tissue engineering due to biocompatibility.
View Article and Find Full Text PDFCollagen constituting the extracellular matrix has been widely used as biocompatible material for human use. In this study, we have selected duck's feet for extracting collagen. A simple method not utilizing harsh chemical had been employed to extract collagen from duck's feet.
View Article and Find Full Text PDFSilk fibroin has recently become an important biomaterial for tissue engineering application. In this study, silk fibroin nanomatrix was fabricated by electrospinning and evaluated as wound dressing material in a burn rat model. The wound size reduction, histological examination, and the quantification of transforming growth factor TGF-β1 and interleukin IL-1α, 6, and 10 were measured to evaluate the healing effects.
View Article and Find Full Text PDFSilk fibroin (SF) is a natural polymer widely used and studied for diverse applications in the biomedical field. Recently, genetically modified silks, particularly fluorescent SF fibers, were reported to have been produced from transgenic silkworms. However, they are currently limited to textile manufacturing.
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