Publications by authors named "Janet Le"
Background The COVID-19 pandemic and subsequent guidelines have had a substantial effect on social norms. This likely affected self-report assessment of psychopathology, namely those that assess obsessive-compulsive tendencies routinely used to screen for obsessive-compulsive disorder (OCD). It was hypothesized that self-report assessment of OCD likely produces inflated, non-discriminating scale scores.
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- Pre-surgical psychological assessments are increasingly required in the U.S. before surgeries for chronic back pain, with the MMPI-3 being a focal point of evaluation.
- A study involving 909 patients investigated the effectiveness of the MMPI-3 alongside self-reports on pain, disability, and emotional health before and after surgery.
- The results showed that MMPI-3 scores added up to 9% more predictive power for post-surgical outcomes, with emotional/internalizing dysfunction being the most significant indicator of poorer recovery.
Article Synopsis
- Chronic lymphocytic leukemia (CLL) is a challenging disease that leads to a weakened immune system and makes patients more prone to infections and less responsive to immunotherapies; however, new treatments with BTK inhibitors and venetoclax have shown promise in improving outcomes.
- Epcoritamab, a bispecific antibody that targets both CD3 and CD20, has shown strong clinical effects in treating relapsed non-Hodgkin lymphoma and is being studied for its potential to enhance CLL therapy, particularly when combined with existing treatments.
- Research indicates that epcoritamab promotes T-cell activity and can effectively reduce CLL cellular presence in mouse models, making it a promising candidate for combination therapy with BTK inhibitors
Background: Metabolic and bariatric surgery is effective for sustained weight loss, but binge eating disorder (BED) can be associated with poorer outcomes and lead to weight regain. A common measure used to screen for BED is the Binge Eating Scale (BES). A BES cut-off score of ≥17 previously identified patients who have a high likelihood of meeting criteria for BED.
View Article and Find Full Text PDFExtrapulmonary infections in the immunocompetent population are rare and pose a diagnostic challenge. Upper extremity histoplasmosis without a primary lung infection is uncommon. It is possible to acquire it by inadvertent trauma with direct inoculation.
View Article and Find Full Text PDFPurpose: To identify patterns of age-, gender- and refractive- related changes in Scheimpflug-based anterior chamber depth across the central 8 mm of chamber width, to derive normative models, potentially useful for angle closure disease diagnosis.
Methods: This was a retrospective, cross-sectional study. Scheimpflug photography was used to obtain anterior chamber depth measurements at 57 points across the central 8 mm of the chamber width from one eye of each healthy subject (male Caucasians (n = 189), female Caucasians (n = 186), male Asians (n = 165) and female Asians (n = 181)).