Publications by authors named "Janet L Davis"
Article Synopsis
- Central Serous Chorioretinopathy (CSC) is characterized by retinal detachments due to fluid leakage, often linked to stress, psychiatric issues, or corticosteroid use, prompting a study to investigate BALAD as a potential biomarker for CSC severity.
- The research involved a global case-control study of patients with CSC, assessing clinical characteristics, risk factors, and OCT findings in those with and without Bacillary Layer Detachment (BALAD) to better understand its implications in diagnosis and treatment.
- Results showed 37 patients with CSC and BALAD, revealing distinct clinical features on examination and OCT, compared to a control group without BALAD, suggesting significant differences in the manifestation of CSC.
Article Synopsis
- - The survey, developed by the International Uveitis Study Group, aimed to assess how uveitis and retina specialists use current terminology and multimodal imaging (MMI) for diagnosing white dot syndromes (WDS).
- - Out of 432 initial respondents, 263 completed the survey, revealing that most participants specialize in uveitis and utilize MMI, with nearly 90% using it for WDS diagnosis but showing varied usage of the term WDS.
- - The findings suggest a strong consensus among specialists for redefining WDS based on anatomical location rather than the current clinical term, emphasizing MMI's role in enhancing diagnostic precision.
A 61-year-old woman had worsening vision for 12 years associated with progressive patchy macular chorioretinal atrophy. There was latent tuberculosis and angioid streaks. Testing revealed a pathogenic variant of PRPH2 and a heterozygous ABCC6 variant.
View Article and Find Full Text PDFBackground: Nephrologists routinely provide end-of-life care for patients with kidney failure (KF) on maintenance dialysis. Involvement of primary care and palliative care physicians may enhance this experience.
Objective: The objective was to describe outpatient care patterns in the last year of life and the end-of-life acute care utilization for patients with KF on maintenance dialysis.
This pilot study aimed to evaluate the Retinal Function Imager (RFI) for visualizing retinal vasculature and assessment of blood flow characteristics in patients with retinal vasculitis. The RFI is a non-invasive imaging device measuring the blood flow velocity (BFV) in secondary and tertiary retinal vessels using hemoglobin as an intrinsic motion-contrast agent. To test the feasibility of the RFI for patients with retinal vasculitis, capillary perfusion maps (nCPMs) were generated from 15 eyes of eight patients (five females; mean age: 49 ± 12 years) with a mean uveitis duration of 74 ± 85 months.
View Article and Find Full Text PDFPurpose: To assess the validity of retinal vasculitis as the preferred diagnostic term for multiple conditions.
Design: Perspective.
Methods: This Perspective is based on expert opinion and review of literature focused on the current nosology and pathology of retinal vasculitis.
Occlusive Retinal Vasculitis After a Single Injection of Pegcetacoplan.
J Vitreoretin Dis
January 2024
To describe a patient with retinal vasculitis after a single intravitreal injection (IVI) of pegcetacoplan. A case and its findings were analyzed. An 80-year-old woman was treated with pegcetacoplan for subfoveal geographic atrophy.
View Article and Find Full Text PDFTo analyze post-marketing cases of retinal vasculitis after intravitreal pegcetacoplan. The American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee as well as an expert panel performed a retrospective review of cases of retinal vasculitis reported to the ASRS. Clinical and imaging characteristics were reviewed for evidence of retinal vasculitis and analyzed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the awareness and diagnostic practices related to monogenic uveitis (mU) among uveitis specialists through an anonymous survey conducted with members of the Autoinflammatory Diseases Alliance and International Uveitis Study Group.
- Results showed that a majority of participants rated their knowledge of mU as poor, with 60.4% identifying NOD2 as the primary gene, and success rates in clinical scenarios varied significantly, especially among those in multidisciplinary teams.
- The findings highlight knowledge gaps and barriers in prescribing disease-modifying anti-rheumatic drugs (DMARDs), suggesting that the results could guide the development of better clinical guidelines and improve patient care.
Purpose: To assess longitudinal relationships among visual function and anatomical measures of gene therapy in G11778A Leber hereditary optic neuropathy (LHON).
Design: Phase 1 clinical trial.
Methods: This was a single-institution study of patients with G11778A LHON.
Article Synopsis
- A healthy 27-year-old woman with biallelic RPE65 gene mutations experienced panuveitis and exudative retinal detachments after undergoing gene therapy with voretigene neparvovec-rzyl.
- Post-surgery, her vision initially improved but declined significantly by week 6 due to complications, which were linked to inflammation and genetic factors.
- The case suggests that surgery-induced sympathetic ophthalmia could be a rare but serious risk following bilateral eye procedures, highlighting the importance of informed consent regarding potential complications.
Aims: To present current practice patterns in the diagnosis and management of Cytomegalovirus anterior uveitis (CMV AU) by uveitis experts worldwide.
Methods: A two-round modified Delphi survey with masking of the study team was performed. Based on experience and expertise, 100 international uveitis specialists from 21 countries were invited to participate in the survey.
Article Synopsis
- The study aimed to evaluate and create consensus guidelines among global uveitis specialists regarding the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) associated anterior uveitis (AU).
- An online Delphi survey gathered responses from 76 uveitis experts across 21 countries, with findings leading to the establishment of treatment guidelines via the TITAN working group.
- Key conclusions highlighted specific diagnostic signs for HSV and VZV AU, preferred use of valacyclovir for treatment, and a variety of opinions on treatment duration and managing recurrences.
The spectrum of COVID-19-associated chorioretinal vasculopathy.
Am J Ophthalmol Case Rep
September 2023
Purpose: Although conjunctivitis represents the most common ocular manifestation of COVID-19 infection, sight-threatening retinal involvement has been reported. Herein, we report and characterize with multimodal retinal imaging 5 cases of acute vision loss secondary to presumed chorioretinal vasculopathy temporally associated with COVID-19 infection with varying severity, visual morbidity, and treatment response, and review the available literature on the association between COVID-19 infection and retinal microvascular changes.
Design: Observational case series and literature review.
Purpose: Exogenous endophthalmitis (ExE) results from microbial infection as a complication of ocular surgery, penetrating ocular trauma, and intraocular foreign bodies. We herein review the classification of ExE, etiological agents, differential diagnosis and therapeutic challenges.
Methods: Narrative Literature Review.
Multimodal imaging in the diagnosis and management of ophthalmia nodosa.
Am J Ophthalmol Case Rep
December 2022
Purpose: Ophthalmia nodosa (ON) is a rare but important disease describing ocular inflammation caused by injury from insect hairs ("setae"). Type V ON occurs when there is vitreoretinal involvement. Treatment with systemic steroids are first-line, but vitrectomy is indicated in resistant cases.
View Article and Find Full Text PDFAN 82-YEAR-OLD WOMAN WITH RETINAL VASCULAR SHEATHING AND VITREOUS HEMORRHAGE.
Retin Cases Brief Rep
June 2023
Purpose: This report describes a case of hereditary transthyretin amyloidosis in an 82-year-old woman who presented with bilateral retinal arteriolar vascular sheathing and vitreous hemorrhage in one eye.
Methods: The patient underwent a full history, physical examination, genetic workup, and cardiac imaging to establish the diagnosis. Fundus photographs, optical coherence tomography, fluorescein angiography, and indocyanine green angiography were performed throughout the patient's treatment course.
Introduction: Vitreoretinal lymphoma is a rare ocular cancer with high morbidity and mortality despite treatment. Diagnosis by cytopathology is often delayed, and various molecular and image-based investigations have been developed. Diverse treatments are used, but there is a limited medical evidence to differentiate their effectiveness.
View Article and Find Full Text PDFPurpose: To evaluate the clinical features, operative techniques, and surgical outcomes of patients who underwent surgery for acute retinal necrosis (ARN)-related retinal detachment (RD).
Design: Retrospective, longitudinal, consecutive case series.
Participants: Patients with polymerase chain reaction-positive ARN presenting from 2011 to 2021 who underwent vitreoretinal surgery for ARN-related RD at our institution.
Background: An effective therapy to reduce the number and severity of HLA-B27-related acute anterior uveitis (AAU) recurrences represents a clinical need. Curcumin is a promising therapeutic option in various inflammatory eye diseases. To enhance its absorption and eye tissue selectivity, a phospholipidic-curcumin complex (PHBC) has been formulated (Iphytoone®, Eye Pharma S.
View Article and Find Full Text PDFPurpose: The primary purpose of this study was to assess vascular retinal findings temporally related to COVID-19 vaccination. With greater information regarding all possible future adverse events, we hope to understand the real dimension and relevance of what was presented.
Methods: Eleven patients with visual complaints after COVID-19 vaccination were enrolled.
Purpose: To assess safety of gene therapy in G11778A Leber hereditary optic neuropathy (LHON).
Design: Phase 1 clinical trial.
Methods: Setting: single institution.