Multicenter randomized phase 3 study of a sustained-release intracanalicular dexamethasone insert for treatment of ocular inflammation and pain after cataract surgery.

Purpose: To assess the efficacy and safety of a sustained-release intracanalicular dexamethasone insert for the treatment of postoperative ocular inflammation and pain in patients having cataract surgery.

Setting: Twenty-one United States sites.

Design: Prospective multicenter randomized parallel-arm double-masked vehicle-controlled phase 3 study.

Novel 3D computer-automated threshold Amsler grid visual field testing of scotomas in patients with glaucoma.

Purpose: Three-dimensional (3D) computer-automated threshold Amsler grid testing was used to identify and characterize scotomas typical of glaucoma.

Methods: The 3D test exhibits a grid on a computer screen at a preselected grayscale and angular resolution, and allows patients to trace those areas on the grid that are missing in their visual field using a touch screen. Eleven eyes in patients with an established diagnosis of glaucoma were examined according to the above protocol.

Quantitative analysis of central visual field defects in macular edema using three-dimensional computer-automated threshold Amsler grid testing.

Purpose: To evaluate the central visual field (CVF) with specialized Amsler grid testing methods that include contrast sensitivity evaluation, in an attempt to detect abnormalities not identified with standard methods and to define new patterns of CVF deficits in two different diseases.

Methods: 3D computer-automated threshold Amsler grid testing (3D-CTAG) was performed at five levels of contrast in one eye of 37 patients with diabetic macular edema (DME, n = 16) and exudative age-related macular degeneration (AMD, n = 21).

Results: 3D-CTAG abnormalities were detected in six patients (16%) who had no abnormalities with conventional Amsler grid testing.

Response pattern asymmetry of binocular vision vertical fusion amplitudes in a normal population.

Purpose: To compare the maximum vertical fusion amplitudes in vertical directions (response pattern by respective higher eye), to investigate for possible asymmetry.

Methods: Vertical fusion amplitude (VFA) was measured in one hundred normal adults with normal single binocular vision using a computer based device that produced a gradually increasing, but optically distant test distance, Vertical fusion amplitudes in the vertical left- over-right (L/R, elevation of the left eye above the right eye) pattern direction were compared to the vertical fusion amplitudes in the vertical right-over-left direction pattern(R/L).

Results: The mean VFA was 4.