Publications by authors named "Janet K Grimsley"
A catalytic bioscavenger with broad substrate specificity for the therapeutic and prophylactic defense against recognized chemical threat agents has been a long standing objective of civilian and military research. A catalytic bioscavenger utilizing the bacterial enzyme organophosphorus hydrolase (OPH) is characterized in these studies, and has potential application for both military and civilian personnel in threat scenarios involving either nerve agents or OP pesticides. The present study examines the effects of PEGylation on the biochemical and pharmacological characteristics of OPH.
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- Organophosphorus hydrolase (OPH) is an enzyme that breaks down harmful chemicals like pesticides and nerve agents.
- Scientists have created versions of this enzyme that work better, with one special version called H254R showing different effects on certain chemicals.
- The study showed that the way the enzyme is shaped helps it work differently, finding a new spot on the surface where certain inhibitors can bind, affecting how it breaks down harmful substances.