Fertility Sparing Medical Management Options in Gynecologic Cancers.

There is an increasing use of medical management for gynecologic cancers given the rise in neoadjuvant therapies, delayed childbearing, and use of assisted reproductive technology. Chemotherapy, albeit broadly used in most gynecologic cancers, lacks long term data with respect to its associated gonadotoxicity and potential adverse pregnancy outcomes. Immunotherapy and other targeted therapies that have demonstrated promising responses in other tumor types are increasingly being studied in gynecologic malignancies.

Endometrial cancer of both uterine horns in a premenopausal patient with uterine didelphys: Surgical approach and considerations for adjuvant treatment.

•Concomitant diagnosis of endometrial cancer (EC) and uterine didelphys is rare.•Robotic surgery can safely be performed in patients with EC uterine didelphys.•A multidisciplinary team is required to approach treatment and cancer surveillance in those with Mullerian anomalies.

Endometrial cancer recurrence after the use of a uterine manipulator during laparoscopic surgery.

Objective: Minimally invasive surgery (MIS) is the standard approach for the staging and treatment of early-stage endometrial cancer (EC) and often includes use of a uterine manipulator. Uterine perforation is a known risk in this setting, and the impact of perforation and tumor spillage on cancer recurrence is largely unknown. The aim of this study was to assess the association between uterine perforation and/or tumor spillage at the time of MIS for low-grade, early-stage EC on disease recurrence.