Publications by authors named "Janelle Louise Harris"
Protein-protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding sites, as antibodies cannot cross the cell membrane to reach such target sites. In recent years, peptides smaller size and balance of conformational rigidity and flexibility have made them promising candidates for targeting challenging binding interfaces with satisfactory binding affinity and specificity.
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- When DNA gets damaged, a process called end resection helps fix it without making mistakes.
- A protein called EXO1 helps with this fixing, but it needs to be carefully controlled to avoid causing problems.
- New research shows that when DNA is damaged, EXO1 gets broken down quickly by a system in our cells, which helps make sure the repair is done correctly without going too far.
Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. Although CDKs are known to control initiation of resection, their role in regulating long-range resection remains elusive. Here we show that CDKs 1/2 phosphorylate the long-range resection nuclease EXO1 at four C-terminal S/TP sites during S/G2 phases of the cell cycle.
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