Publications by authors named "Jane van der Schaaf"
Article Synopsis
- - Nearly 75% of women experience vulvovaginal candidiasis (VVC) in their lifetime, leading to significant quality of life issues, yet the reasons for its development, such as whether the disease-causing strains differ from commensal strains, are still unclear.
- - Research on C. albicans strains shows no genetic differences between VVC-causing and colonizing strains; however, VVC strains exhibit stronger interaction with vaginal epithelial cells, resulting in increased fungal proliferation and cell shedding.
- - RNA sequencing revealed different signaling pathways activated during infections, particularly the type I interferon pathway, suggesting that the pathogenic potential of VVC strains may be related to their ability to exploit epithelial responses differently.
