Orthodontically induced changes to the genetic profile in periodontal ligament tissue and cytokine release in gingival crevicular fluid - A pilot investigation.

Background/purpose: It has been known that genetic factors influence orthodontic tooth movement, however, scientific research on humans is lacking. Therefore, this study aimed to investigate dynamic changes to the genetic profile in human periodontal ligament (PDL) tissue and cytokine release in gingival crevicular fluid (GCF) during the first 28 days of orthodontic treatment.

Materials And Methods: Fifteen teeth from three patients were recruited.

A scoping review on the availability and utilization of essential opioid analgesics in Sub-Saharan Africa.

Background: Management of acute, post-operative, and chronic pain requires access to and availability of opioids. While often oversupplied in high-income countries, significant shortages exist in low- and middle-income countries. We conducted a scoping review on availability and usage of opioids in Sub-Saharan Africa (SSA).

Histological analysis on tissues around orthodontically intruded maxillary molars using temporary anchorage devices: A case report.

Before progress was recently made in the application of temporary anchorage devices (TADs) in bio-mechanical design, orthodontists were rarely able to intrude molars to reduce upper posterior dental height (UPDH). However, TADs are now widely used to intrude molars to flatten the occlusal plane or induce counterclockwise rotation of the mandible. Previous studies involving clinical or animal histological evaluation on changes in periodontal conditions after molar intrusion have been reported, however, studies involving human histology are scarce.

Availability and Use of Essential Opioid Analgesics in Sub-Saharan Africa: A Scoping Review Protocol.

Introduction: The treatment of acute, peri-operative, and chronic pain by healthcare practitioners and health systems requires appropriate access to and availability of essential opioid medications. While opioids are often oversupplied and overprescribed in high-income countries, there are significant inequities as many low- and middle-income countries (LMICs) experience severe shortages. In fact, while the richest 10% in the world reside in countries receiving almost 90% of all available opioids, 50% of the poorest in the world reside in countries receiving just 1% of all available opioids.

Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse models.

Background/purpose: Previously we demonstrated up-regulation of matrix metalloproteinase-3 () in human osteoblasts under compression and in bony specimens of experimental orthodontic tooth movement (OTM). Here, we studied the temporal characteristics of compression stimulation in human and mouse osteoblast cell lines, and generated a transgenic mouse model for assessing the expression during OTM.

Materials And Methods: We investigated expressions in human and murine osteoblasts through RT-PCR and luciferase assay, after compressive force loading.

Differences of condylar changes after orthognathic surgery among Class II and Class III patients.

Background/purpose: The nature of susceptibility to condylar resorption after orthognathic surgery can be different between skeletal Class II and Class III populations, which was addressed by few in the past. The aim of the present study was to use cone-beam computed tomographic (CBCT) images to investigate the displacement and morphological changes of temporomandibular joints (TMJs) in patients received orthodontic treatment combined with orthognathic surgery.

Methods: Both Class III (n = 34) and Class II (n = 17) patients were compared through overall and regional superimpositions of the initial and posttreatment CBCTs.

Mechanoregulation of osteoblast-like MG-63 cell activities by cyclic stretching.

Background/purpose: Mechanical loading plays an important role in regulating bone formation and remodeling. Relevant mechanical stretching can increase the proliferation and differentiation of osteoblastic cells in vitro. However, little is known about the effects of supraphysiological high-level mechanical stretching on the growth and cell cycle progression of osteoblastic cells.

Transverse and sagittal angulations of proximal segment after sagittal split and vertical ramus osteotomies and their influence on the stability of distal segment.

Background/purpose: This study aimed at comparing the transverse and sagittal angulations of proximal segment after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO), and examining their influences on the stability of distal segment.

Methods: Patients who received SSRO (n = 21) or IVRO (n = 11) for mandibular setback were included. Lateral and posteroanterior cephalograms taken within 1 month before surgery (T1), within 1 week after surgery (T2), and at least 6 months after surgery (T3) were analyzed.

The effects of acellular amniotic membrane matrix on osteogenic differentiation and ERK1/2 signaling in human dental apical papilla cells.

The amniotic membrane (AM) has been widely used in the field of tissue engineering because of the favorable biological properties for scaffolding material. However, little is known about the effects of an acellular AM matrix on the osteogenic differentiation of mesenchymal stem cells. In this study, it was found that both basement membrane side and collagenous stroma side of the acellular AM matrix were capable of providing a preferential environment for driving the osteogenic differentiation of human dental apical papilla cells (APCs) with proven stem cell characteristics.

Relationship between age at menarche and skeletal maturation stages in Taiwanese female orthodontic patients.

Background/purpose: The age at menarche reflects a pubertal girl's physiologic maturity. The aims of this study were to evaluate the relationship between the age at menarche and skeletal maturation in female orthodontic patients.

Methods: Hand-wrist radiographs and lateral cephalometric radiographs from 304 adolescent female subjects (age, 8-18.

Morphometric analysis of mandibular growth in skeletal Class III malocclusion.

Background: The craniofacial growth patterns of untreated individuals with skeletal Class III malocclusion have rarely been systemically investigated. This study used morphometric techniques to investigate the growth characteristics of the mandible in individuals with skeletal Class III malocclusion.

Methods: Lateral cephalometric head films of 294 individuals with untreated skeletal Class III malocclusion (134 males, 160 females) were selected and divided into five triennial age groups (T1-T5) and by gender to identify the morphologic characteristics and sexual dimorphism in changes of mandibular growth.

Evaluation of the changes in midfacial configuration after face mask therapy in skeletal Class III growing patients by morphometric analysis techniques.

Background And Purpose: The prevalence of Angle Class III malocclusion is relatively high in Taiwan. For children who suffer from maxillary retrognathia, face mask therapy is a promising treatment modality. The purpose of this study was to evaluate the changes in midfacial configuration after face mask therapy in skeletal Class III growing patients by morphometric analysis techniques.

Thin-plate spline analysis of the effects of face mask treatment in children with maxillary retrognathism.

Background: Face mask therapy is indicated for growing patients who suffer from maxillary retrognathia. Most previous studies used conventional cephalometric analysis to evaluate the effects of face mask treatment. Cephalometric analysis has been shown to be insufficient for complex craniofacial configurations.

Long-term effect of pulsed Nd:YAG laser irradiation on cultured human periodontal fibroblasts.

Background And Objectives: The purpose of this study was to investigate the long-term effect of Nd:YAG laser irradiation on cultured human periodontal fibroblasts (hPF).

Study Design/materials And Methods: The cultured hPF were irradiated by pulsed Nd:YAG laser. The power delivery was 50 mJ x 10 pps (pulse per second) with irradiation duration 60, 120, 180, or 240 seconds.

The effects of differences in landmark identification on the cephalometric measurements in traditional versus digitized cephalometry.

The aim of this study was to explore the effects of differences in landmark identification on the values of cephalometric measurements on digitized cephalograms in comparison with those obtained from original radiographs. Ten cephalometric radiographs were randomly selected from orthodontic patients' records. Seven orthodontic residents identified 19 cephalometric landmarks on the original radiographs and digitized images.