An Elective Course to Train Student Pharmacists to Provide Culturally Sensitive Health Care.

To design and implement an elective course that prepares student pharmacists to provide culturally sensitive health care by developing their knowledge, self-confidence, and clinical and communication skills for working with patients from various cultural backgrounds during community health screenings. In this one-credit-hour elective course, second- and third-year pharmacy students were taught about chronic disease states affecting various minorities, approaches to improve their communication with patients from various cultural backgrounds, and proper use of cardiometabolic equipment during health screening events. After a health screening event at the end of the course, knowledge scores, self-confidence, clinical skills, and communication skills were compared between students who took the elective course and those in a control group.

Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity.

Tissue macrophages have an embryonic origin and can be replenished in some tissues under steady-state conditions by blood monocytes. However, little is known about the residency and properties of infiltrating monocytes after an inflammatory challenge. The meninges of the central nervous system (CNS) are populated by a dense network of macrophages that act as resident immune sentinels.

Implementation of a cefazolin-based stewardship pathway for methicillin-susceptible Staphylococcus aureus bloodstream infections paired with infectious diseases consultation.

Methicillin-susceptible Staphylococcus aureus (MSSA) infections have been successfully treated both with cefazolin and antistaphylococcal penicillins; cefazolin appears effective in MSSA bloodstream infections (BSIs). Thus, our antimicrobial stewardship programme (ASP) implemented a clinical pathway supporting cefazolin use in MSSA-BSIs and restricting oxacillin use to infectious diseases (ID) consultation due to cefazolin's lower cost and more convenient dosing. This before and after quasi-experimental study was conducted to describe the impact on outcomes and process of care measures associated with implementing this pathway among patients with MSSA-BSI.

Circulating Tumour Cells as an Independent Prognostic Factor in Patients with Advanced Oesophageal Squamous Cell Carcinoma Undergoing Chemoradiotherapy.

The role of circulating tumour cells (CTCs) in advanced oesophageal cancer (EC) patients undergoing concurrent chemoradiotherapy (CCRT) remains uncertain. A negative selection protocol plus flow cytometry was validated to efficiently identify CTCs. The CTC number was calculated and analysed for survival impact.

Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells.

SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting cells of different breast cancer subtypes and tamoxifen sensitivity.

Carbapenem susceptibility breakpoints, clinical implications with the moving target.

Carbapenems are primary agents used to treat a variety of Gram-negative multi-drug resistant infections. In parallel with increasing use, increasing resistance to carbapenem agents has manifested as increased minimum inhibitory concentrations (MICs). To attempt to improve clinical outcomes with carbapenems, the Clinical Laboratory Standards Institute and the Food Drug Administration decreased susceptibility breakpoints.

Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).

Introduction: Aurora kinase A, B and C, members of serine/threonine kinase family, are key regulators of mitosis. As Aurora kinases are overexpressed in many of the human cancers, small-molecule inhibitors of Aurora kinase have emerged as a possible treatment option for cancer.

Areas Covered: In 2009 and 2011, the literature pertaining to Aurora kinase inhibitors and their patents was reviewed.

Survivin - biology and potential as a therapeutic target in oncology.

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule.

Seeking affective health care: Korean immigrants' use of homeland medical services.

This paper explores the phenomenon of migrants returning to their country of origin for health care. Specifically, it examines the case of Korean immigrants to New Zealand making trips to their homeland to obtain medical operations. We situate our inquiry at the intersection of literatures on home, therapeutic spaces and health care consumption.