Publications by authors named "Jane P Y Ho"
Diabetologia
February 2025
Article Synopsis
- Monogenic diabetes results from rare gene mutations affecting beta cell function, and this study examines how common variants may also influence young-onset type 2 diabetes (YOD) and related health issues.
- Researchers created a weighted polygenic risk score (wPRS) using data from individuals with and without YOD to explore the association of 135 common variants across 34 monogenic diabetes genes.
- The findings indicate that higher wPRS correlates with an increased likelihood of YOD and a higher risk for cardiovascular and kidney events in individuals with type 2 diabetes.
