Publications by authors named "Jane Ooi"
Article Synopsis
- The EPHOS-B trial aimed to evaluate the effects of perioperative anti-HER2 therapy on tumor growth and cell death in women with HER2-positive breast cancer before surgery.
- In a multicenter study involving 257 patients, various treatment groups including trastuzumab and lapatinib were tested, revealing that lapatinib led to a higher percentage of tumor response compared to trastuzumab or no treatment.
- The study found that early decreases in tumor proliferation (Ki67) are linked to better long-term outcomes, supporting a potential individualized approach to reduce treatment intensity for certain patients.
Within the United Kingdom, a recent change in "Best Practice Guidance" has suggested that mammograms for symptomatic breast patients, with a clinically benign examination, should be limited to those over 40 years . This has led to anxiety over missing cancer diagnoses in the 35-39 year-old age group. This study aimed to assess the impact of the new guidance upon a NHS Breast unit with a particular focus on safety.
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