Publications by authors named "Jane Olsson"
J Natl Cancer Inst
August 2006
Article Synopsis
- The study investigates the role of the SOX18 transcription factor in tumor growth and angiogenesis, comparing wild-type mice with those lacking SOX18 or expressing a dominant-negative variant.
- Results showed that tumors in Sox18-null and dominant-negative mice grew slower and had fewer blood vessels than those in wild-type mice, suggesting a crucial role for SOX18 in promoting tumor angiogenesis.
- Additionally, disrupting SOX18 function reduced the proliferation and migration of cancer cells and endothelial cells, indicating that SOX18 might be a valuable target for cancer therapy.
