Publications by authors named "Jane M Allen"
J Antimicrob Chemother
March 2015
Article Synopsis
- The study aimed to create a population model for the pharmacokinetics of intravenous meropenem in adult burn patients, exploring how different dosages affect its effectiveness.
- Researchers administered 1 g of meropenem every 8 hours to patients with burns covering at least 15% of their body, measuring plasma concentrations to fit a PK model and evaluate various dosage regimens through simulations.
- Results indicated that while the standard dosage may work against certain bacteria, higher doses and longer infusion times are recommended for more serious infections or when bacteria have higher minimum inhibitory concentration (MIC) values.
