Publications by authors named "Jane Kruskop"
Article Synopsis
- Alzheimer's disease (AD) is characterized by the buildup of amyloid-β (Aβ) proteins in the brain, which is linked to cognitive decline.
- Physical exercise can help reduce Aβ levels, and a hormone called irisin, released during exercise, has been found to enhance the release of an enzyme (neprilysin) that breaks down Aβ in astrocytes.
- The study identified integrin αV/β5 as the receptor for irisin on astrocytes, highlighting a potential new pathway for developing therapies to combat Alzheimer’s disease.
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising stem cell-derived neurons, astrocytes and microglia, together with peripheral immune cells. We observed an increase in the number of T cells (but not B cells) and monocytes selectively infiltrating into AD relative to control cultures.
View Article and Find Full Text PDFHighlighting Diversity in Neuroscience through Course Content.
J Undergrad Neurosci Educ
December 2020
Slides showcasing research of one or two neuroscientists from diverse backgrounds were added to weekly, learning assistant-led sections in a large (~80 person) primarily lecture course required for neuroscience majors. Students appreciated the slides, and survey data suggests that the slides increased the sense of belonging for both underrepresented and not underrepresented students.
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