A randomized controlled trial of negative co-payments: the CHORD trial.

Objectives: Value-based insurance designs are being widely used. We undertook this study to examine whether a financial incentive that lowered co-payments for blood pressure medications below $0 improved blood pressure control among patients with poorly controlled hypertension.

Study Design: Randomized controlled trial.

A randomized controlled trial of co-payment elimination: the CHORD trial.

Objectives: Efforts to improve adherence by reducing co-payments through value-based insurance design are become more prevalent despite limited evidence of improved health outcomes. The objective of this study was to determine whether eliminating patient co-payments for blood pressure medications improves blood pressure control.

Study Design: Randomized controlled trial.

Randomized trial of lottery-based incentives to improve warfarin adherence.

Background: Poor adherence to medications is a major cause of morbidity and inadequate drug effectiveness. Efforts to improve adherence have typically been either ineffective or too complex to implement in clinical practice. Lottery-based incentive interventions could be a scalable approach to improving adherence.

Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction.

Background: Studies have postulated that cyclooxygenase-2 (COX-2) selective inhibitors affect cardiovascular risk through various mechanisms. Some of these mechanisms could increase risk (for example, inhibition of prostacyclin production), and some could decrease risk (for example, inhibition of inflammation).

Objective: To determine the effect of COX-2 inhibitors on risk for nonfatal myocardial infarction (MI).

The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin.

Objectives: This study was designed to determine if non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) are associated with lower odds of myocardial infarction (MI) and if NANSAIDs, particularly ibuprofen, interfere with aspirin's cardioprotective effect.

Background: The NANSAIDs may reduce the risk of MI but may also interfere with aspirin's cardioprotective effect.

Methods: A case-control study was conducted, with cases of first, nonfatal MI identified prospectively and controls identified randomly from the community.

Enhancement of medication recall using medication pictures and lists in telephone interviews.

Purpose: To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study.

Methods: After a series of indication-specific questions, a list of all available NANSAIDs was read to study participants and a series of pictures was reviewed when available. Recall was defined as enhanced if a participant recalled NANSAID use only after the memory aids.