Co-Production of the 'My SJS Passport' to Support Survivors of Stevens-Johnson Syndrome (SJS) Post Diagnosis and Beyond - A Proof of Concept Study.

Background: Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening reactions that cause blistering of the skin and mucous membranes. Survivors can experience long term physical and psychological complications. The 'My SJS Passport' was co-produced by the Patient and Public Involvement group and research team at the Wolfson Centre for Personalised Medicine to improve the care and experiences of survivors.

In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski's Base.

p-Phenylenediamine (PPD) is a component of hair dye formulations that is associated with T-cell mediated allergic contact dermatitis. Antigen-specific T-cells from allergic contact dermatitis patients are activated with either PPD or the oxidation product, Bandrowski's base. In nonallergic individuals, T-cells that are activated by Bandrowski's base, but not by PPD, are readily detectable.

Nursing student placements in clinical research.

Research is part of the remit of the NHS and consequently many patients participate in research studies. Clinical nurses have a vital role in research, since they care for patients who participate in studies and act as patient advocates during research. However, nursing students are rarely provided with an opportunity to undertake a research placement.

Electronic health records for biological sample collection: feasibility study of statin-induced myopathy using the Clinical Practice Research Datalink.

Aims: Electronic healthcare records (EHRs) are increasingly used to store clinical information. A secondary benefit of EHRs is their use, in an anonymized form, for observational research. The Clinical Practice Research Datalink (CPRD) contains EHRs from primary care in the UK and, despite 1083 peer-reviewed research publications, has never been used to obtain pharmacogenetic samples.

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers.

Background: Drug-induced liver injury (DILI) is one of the most common adverse reactions leading to product withdrawal post-marketing. Recently, genome-wide association studies have identified a number of human leukocyte antigen (HLA) alleles associated with DILI; however, the cellular and chemical mechanisms are not fully understood.

Methods: To study these mechanisms, we established an HLA-typed cell archive from 400 healthy volunteers.