Publications by authors named "Jane E Manganaro"
Article Synopsis
- - Parkinson's disease (PD) is primarily caused by the loss of dopamine-producing neurons in the brain, with mutations in the Pink1 and Parkin proteins linked to familial cases of PD.
- - Recent findings show that Pink1 and Parkin also play a role in how peripheral blood cells (PBMCs) manage energy metabolism, impacting immune cell populations by increasing CD4+ T cells while decreasing CD8+ T cells and B cells in rats.
- - The deficiency of Pink1/Parkin contributes to higher platelet counts and increased aggregation of platelets with lymphocytes, which raises the risk of thrombosis, indicating that targeting these proteins could lead to new therapeutic strategies for PD.
Article Synopsis
- Traumatic brain injury (TBI) is a major cause of injury-related death and disability in the U.S., and managing neuroinflammation early is crucial for treatment.
- Pioglitazone, a drug that may reduce inflammation after TBI, shows potential but also has unknown long-term effects that can worsen brain conditions.
- Research in mice indicates that acute/subacute treatment with pioglitazone leads to negative outcomes, including brain damage and behavior changes, highlighting the need for sex-based considerations and further investigation before clinical use for TBI.
Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder and results from the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Pink1 and Parkin are proteins that function together in mitochondrial quality control, and when they carry loss-of-function mutations lead to familial forms of PD. While much research has focused on central nervous system alterations in PD, peripheral contributions to PD pathogenesis are increasingly appreciated.
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