Publications by authors named "Jane A Stewart"
Research Question: The current study aimed to assess knowledge, attitudes and intentions in relation to fertility preservation among children, by proxy, and adolescents with cancer. Although fertility preservation options have been developed to mitigate the adverse long-term effects of life-saving cancer treatment on fertility, fertility is difficult for children and adolescents to conceptualize, especially when they face a cancer diagnosis.
Design: This was a descriptive, semi-quantitative analysis.
Article Synopsis
- There is increasing concern about infertility among young cancer survivors and its impact on their quality of life, leading to a focus on fertility preservation efforts among healthcare professionals.
- A questionnaire was distributed to 88 pediatric and adolescent oncology professionals to identify barriers they face in providing fertility preservation care, with a significant response rate of 55%.
- The study found that all responders acknowledged at least one barrier, mainly related to patient characteristics, while knowledge and policy gaps were more commonly reported by nurses compared to doctors; addressing these issues through education and interdisciplinary collaboration could enhance fertility discussions with patients.
Context: A broad spectrum of GnRH-deficient phenotypes has been identified in individuals with both mono- and biallelic GNRHR mutations.
Objective: The objective of the study was to determine the correlation between the severity of the reproductive phenotype(s) and the number and functional severity of rare sequence variants in GNRHR.
Subjects: Eight hundred sixty-three probands with different forms of GnRH deficiency, 46 family members and 422 controls were screened for GNRHR mutations.
The Royal College of Obstetricians and Gynaecologists Guidelines for the management of infertility in secondary care (1998) states that stimulated intrauterine insemination (IUI) has Grade A evidence to confirm its effective use in unexplained infertility. This paper challenges that assertion after closer assessment of the papers upon which it was based. With the current appraisal of the Guidelines as part of the 'scope' of the assessment of infertility management by the National Institute of Clinical Excellence it is important that the guidelines are indeed critically reviewed prior to their updated publication.
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