From Pseudocyclic to Macrocyclic Ionophores: Strategies toward the Synthesis of Cyclic Monensin Derivatives.

There has been a long search for a simple preparation of new cyclic analogues of ionophore antibiotics. We report a simple and general synthesis of three new cyclic derivatives of polyether ionophore, monensin A (MON). The application of the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes to macrocyclization results in a concise, synthetic route to monensin lacton or lactam in only 4 steps.

Synthesis, X-ray studies and antiproliferative activity of novel lasalocid amides.

Seeking new drug candidates among compounds of natural origin is an effective and widely used method of fighting various diseases, especially cancer. Lasalocid acid is one of the naturally occurring polyether ionophore antibiotics, which also exhibits interesting anticancer activity. Therefore, to expand the knowledge about the anticancer properties of lasalocid derivatives, a series of its new amides were synthesized and their antiproliferative activity against cancer cell lines was studied.

In vitro and in silico studies of a Zn(II) complex as a potential therapeutic agent for breast cancer.

Breast cancer (BC) is one of the most life-threatening diseases of women's health worldwide. This work was conducted to assess the anti-BC potency of a new Zn(II)-based complex. The Zn(II) complex coordinated to dimethoxy-substituted bipyridine was synthesized and its molecular structure was elucidated as [Zn(bpy)](clo) (bpy-Zn) by single-crystal X-ray diffraction, bpy represents 4,4'-dimethoxy-2,2'-bipyridine.

Post-Synthetic Modification of a 1D Mixed-Linker Zn(II) Coordination Polymer for Acid-Catalyzed Alcoholysis of Epoxides.

Rational design of heterogeneous acid catalysts possessing uniform dispersion of active sites plays a significant role in the catalytic performance. In the present work, a coordination polymer, [Zn(4,4'-bpy)(μ-Hbtc)(HO)] ⋅ 2HO (Zn-CP), was solvothermally synthesized using 4,4'-bpy (=4,4'-bipyridine) and Hbtc (=1,3,5-benzenetricarboxylic acid) mixed linkers. Single crystal X-ray analysis of the polymer displayed that Zn-CP chains were decorated with 4,4'-bpy having unidentate coordination fashion.

Unique Use of Dibromo-L-Tyrosine Ligand in Building of Cu(II) Coordination Polymer-Experimental and Theoretical Investigations.

Although the crystals of coordination polymer {[CuCl(O,O'-L-BrTyr)]}n (1) (L-BrTyr = 3,5-dibromo-L-tyrosine) were formed under basic conditions, crystallographic studies revealed that the OH group of the ligand remained protonated. Two adjacent [CuCl(L-BrTyr)] monomers, bridged by the carboxylate group of the ligand in the bidentate bridging mode, are differently oriented to form a polymeric chain; this specific bridging was detected also by FT-IR and EPR spectroscopy. Each Cu(II) ion in polymeric compound 1 is coordinated in the xy plane by the amino nitrogen and carboxyl oxygen of the parent ligand and the oxygen of the carboxyl group from the symmetry related ligand of the adjacent [Cu(L-BrTyr)Cl] monomer, as well as an independent chlorine ion.

Ultrasound-assisted synthesis of a Eu-functionalized Zn coordination polymer as a fluorescent dual detection probe for highly sensitive recognition of Hg and L-Cys.

A new Zn coordination polymer (CP) based on 2,3-pyrazine dicarboxylic acid (Hpzdc) and 4,4'-bipyridine (bpy) (ZCP) was synthesized using a facile slow evaporation method. Single-crystal X-ray diffraction revealed that ZCP is a two-dimensional porous CP, [Zn(pzdc)(bpy)(HO)], with van der Waals forces as the dominant interaction within its layers forming a 6 network. Employing energetic ultrasound irradiation, nanoscale ZCP (nZCP) was successfully synthesized and Eu ions were incorporated within its host lattice (Eu@nZCP).

Novel Combretastatin A-4 Analogs-Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity.

Combretastatins isolated from the tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt the polymerization process of microtubules in tubulins, causing mitotic arrest. In vitro and in vivo studies have proven that some combretastatins exhibit antitumor properties, and among them, combretastatin A-4 is the most active mitotic inhibitor.

Bacterial Cellulose-Based MOF Hybrid as a Sensitive Switch Off-On Luminescent Sensor for the Selective Recognition of l-Histidine.

In this study, a stable and luminescent UiO-66-NH () and its derivative Cu@ were prepared and utilized successfully as an Off-On luminescent sensing platform for effective, selective, as well as rapid (5 min) detection of l-Histidine (l-His). The reveals efficient quenching in the presence of Cu ions through photoinduced electron transition (PET) mechanism as a dynamic quenching process (in the range of 0.01-1 mM) forming Cu@ sensing platform.

Quality of Surgical Outcome Reporting in Randomised Clinical Trials of Multimodal Rectal Cancer Treatment: A Systematic Review.

Introduction: Randomised controlled trials (RCTs) continue to provide the best evidence for treatment options, but the quality of reporting in RCTs and the completeness rate of reporting of surgical outcomes and complication data vary widely. The aim of this study was to measure the quality of reporting of the surgical outcome and complication data in RCTs of rectal cancer treatment and whether this quality has changed over time.

Methods: Eligible articles with the keywords ("rectal cancer" OR "rectal carcinoma") AND ("radiation" OR "radiotherapy") that were RCTs and published in the English, German, Polish, or Italian language were identified by reviewing all abstracts published from 1982 through 2022.

Synthesis and characterization of a new copper-based polyoxomolybdate and its catalytic activity for azide-alkyne cycloaddition reaction under UV light irradiation.

A new organic-functionalized Cu-based Anderson-type polyoxomolybdate, namely (CHN)[Na(HO)][CHCuMoNO]·2(HO) (Cu-POM), was synthesized via a simple one-pot reaction and subsequently characterized using a range of analytical and spectral techniques. Structural investigation by single crystal X-ray diffraction analysis revealed that the polyanion component of the synthesized compound (i.e.

Structural, spectroscopic properties ant prospective application of a new nitropyridine amino N-oxide derivative: 2-[(4-nitropyridine-3-yl)amino]ethan-1-ol N-oxide.

A new nitropyridine amino N-oxide derivative 2-[(4-nitropyridine-3-yl)amino]ethan-1-ol N-oxide was synthesized and its structural and optical properties were described. Its structure obtained from the X-ray diffraction (XRD) studies was related to the Infrared spectroscopy (IR), Raman spectroscopy (RS), electron Ultraviolet-Visible spectroscopy (UV-VIS) and emission spectra measurements. The experimental results were analyzed in terms of theoretical data obtained from quantum chemical Density Functional Theory (DFT) and Natural Bond Orbital (NBO) calculations.

A critical review of the novelties in the development of intravenous nanoemulsions.

Nanoemulsions have gained increasing attention in recent years as a drug delivery system due to their ability to improve the solubility and bioavailability of poorly water-soluble drugs. This systematic review aimed to collect and critically analyze recent novelties in developing, designing, and optimizing intravenous nanoemulsions appearing in articles published between 2017 and 2022. The applied methodology involved searching two electronic databases PubMed and Scopus, using the keyword "nanoemulsion" in combination with "intravenous" or "parenteral".

A new binuclear Ni(II) complex, an effective A-coupling catalyst in solvent-free condition.

A newly binuclear nickel(II) complex, [Ni(en)(ox)](ClO) () (where en = ethylenediamine, and ox = oxalate), has been isolated from a reaction of NiCl·6HO, ethylenediamine, ammonium oxalate and sodium perchlorate in water and its crystal structure has been determined by X-ray crystallography and infra-red techniques. Compound was successfully employed to promote the one-pot reaction of aldehydes, amines and acetylenes for the construction of corresponding propargylamines under solvent-free media with fine yields. Further studies reveal this catalytic system can be refreshed and used again in five runs.

Spectroscopic and optical properties of 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one as a component of herbicides.

The herbicides azafenidin [(2-(2,4-dichloro-5-prop-2-ynoxyphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-one)] and flumetsulam [(N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide)] were subjected to IR, Raman, UV-Vis and emission studies. As triazolopyridine is the most prominent and active component of these herbicides, this molecule was characterised by XRD studies, FTIR, Raman, UV-Vis and emission spectra. The experimental data were compared to the results of the DFT quantum chemical calculations carried out for its optimised structure, IR intensities and Raman activities, HOMO-LUMO transitions, and energies of the singlet and triplet states.

Valve-in-valve transcatheter transfemoral mitral valve implantation (ViV-TMVI): Characteristics and early results from a nationwide registry.

Background: Valve-in-valve transcatheter transfemoral mitral valve implantation (ViV-TMVI) is an emerging treatment alternative to reoperation in high-surgical risk patients with failed mitral bioprostheses.

Aim: We aimed to describe the characteristics of ViV-TMVI and evaluate its 30-day outcomes in the Polish population.

Methods: A nationwide registry was initiated to collect data on all patients with failed mitral bioprosthesis undergoing ViV-TMVI in Poland.

Incarerated femoral hernia in women - A critical view on approach options.

Introduction And Importance: In the literature there is few information on femoral hernias while best surgical approach to groin hernia in women is in recent discussion ([1], [2]). Focused on femoral hernia our purpose is to present a possible pathway for incarcerated female hernia approach demonstrated on four cases.

Case Presentation: Four female patients (77-90 y) with suspected incarcerated inguinal unilateral hernia undergoing repair at our department between December 2017 and December 2018 are presented.

Efficient modulation of a barium metal-organic framework using amino acids.

In recent years, significant advances have been made in the precise control of the physical properties of metal-organic frameworks (MOFs) via the linker-modulated method in which modulators compete with linkers and impose kinetic limitations through crystal growth. In this regard, the structure of a new barium-organic framework [Ba(HBTC)(HO)], BaBTC (BTC = 1,3,5-benzene tricarboxylic acid) is introduced, which allows the competitive coordination strategy and growth orientation of an alkaline-earth metal-organic framework (AEMOF) to be probed without sacrificing phase purity, porosity and crystallinity. The modulator effect of an assortment of amino acids on the particle size and morphology of BaBTC is investigated.

Synthesis, Structure, and UV-Vis Characterization of Antimony(III) Phthalocyanine: [(SbPc)(SbI)(SbBr)].

A new antimony(III)-phthalocyanine complex with the formula of [(SbPc)(SbI)(SbBr)] has been obtained in the reaction of pure antimony powder with phthalonitrile under the oxidation conditions by iodine monobromide vapors. The complex crystallizes in the centrosymmetric space group of the triclinic system. Both independent (SbPc) units exhibit non-planar conformation, since the Sb(III) is larger than the equilibrium cavity size of the ring and cannot be accommodated without its expansion; thus, the metal protrudes out of the cavity, forming a saucer shape.

The Structural and Optical Properties of 1,2,4-Triazolo[4,3-]pyridine-3-amine.

The structural and spectroscopic properties of a new triazolopyridine derivative (1,2,4-triazolo[4,3-]pyridin-3-amine) are described in this paper. Its FTIR spectrum was recorded in the 100-4000 cm range and its FT-Raman spectrum in the range 80-4000 cm. The molecular structure and vibrational spectra were analyzed using the B3LYP/6-311G(2d,2p) approach and the GAUSSIAN 16W program.

Directing Crystallization Outcomes of Conformationally Flexible Molecules: Polymorphs, Solvates, and Desolvation Pathways of Fluconazole.

Control over polymorphism and solvatomorphism in API assisted by structural information, e.g., molecular conformation or associations via hydrogen bonds, is crucial for the industrial development of new drugs, as the crystallization products differ in solubility, dissolution profile, compressibility, or melting temperature.

Is the Meckel diverticulum still a bad boy in general surgery? Case report of an intestinal obstruction managed through a single-port access and review of the literature.

In our institution single-port diagnostic laparoscopy is the routine procedure for patients with acute abdominal emergencies. Here, we present a case of intestinal obstruction due to a torqued Meckel diverticulum successfully managed through a single-port incision.

Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1,2-benzothiazine derivatives as novel anti-inflammatory agents.

Novel arylpiperazine-1,2-benzothiazine derivatives have been designed and synthesized as potential anti-inflammatory agents. Their structure and properties have been studied using spectroscopic techniques (H NMR, C NMR, FT-IR), MS, elemental analyses, and single-crystal X-ray diffraction (SCXRD, for compound 7b). This study aimed to evaluate the inhibitory activity of new derivatives against both cyclooxygenase isoforms COX-1 and COX-2 due to the similarity of new compounds to oxicams drugs from the NSAIDs group.

0D to 3D Pr metal-organic networks crystal engineered for optimal iodine adsorption.

Four new praseodymium(III) metal-organic compounds varying in dimensionality from 0D to 3D have been designed and synthesized based on N-heterocyclic polycarboxylic acids, including pyridine-2,6-dicarboxylic acid (Hpydc) and pyrazine-2,3-dicarboxylic acid (Hpzdc). Altering the concentration of piperazine (pip, ancillary ligand) enables control over the dimensionality of the compound by switching between the 0D [Hpip][Hpip][Pr(pydc)]·4HO (I) and the 1D {[Pr(pydc)(Hpydc)(HO)]·4HO} (II) coordination polymer (CP). Upon replacing Hpydc with Hpzdc, CP II is converted to the 2D CP [Pr(pzdc)(Hpzdc)(HO)] (III) and using the metalloligand [Zn(Hpzdc)(HO)], the 3D heterometallic CP {[PrZn(pzdc)(HO)]·2HO} (IV) is formed.